Bernd-Wolfgang Igl
Overview
Explore the profile of Bernd-Wolfgang Igl including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
96
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0
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Recent Articles
1.
Lempp C, Arms S, Bertram C, Klopfleisch R, Igl B, Hezler L, et al.
Toxicol Pathol
. 2024 Jun;
52(5):251-257.
PMID: 38829005
Digitalization of pathology workflows has undergone a rapid evolution and has been widely established in the diagnostic field but remains a challenge in the nonclinical safety context due to lack...
2.
Tug T, Duda J, Menssen M, Bruce S, Bringezu F, Dammann M, et al.
Regul Toxicol Pharmacol
. 2024 Feb;
148:105583.
PMID: 38401761
The alkaline comet assay is frequently used as in vivo follow-up test within different regulatory environments to characterize the DNA-damaging potential of different test items. The corresponding OECD Test guideline...
3.
Tug T, Ickstadt K, Kunz M, Sutter A, Igl B
Regul Toxicol Pharmacol
. 2020 Oct;
118:104808.
PMID: 33127357
The comet assay is one of the standard tests for evaluating the genotoxic potential of a test item able to detect DNA strand breaks in cells or isolated nuclei from...
4.
Kramer F, Voss S, Roessig L, Igl B, Butler J, Lam C, et al.
Eur J Heart Fail
. 2020 Mar;
22(9):1675-1683.
PMID: 32216011
Aims: The effects of vericiguat vs. placebo on high-sensitivity C-reactive protein (hsCRP) and serum uric acid (SUA) were assessed in patients with heart failure with reduced ejection fraction (HFrEF) in...
5.
Igl B, Bitsch A, Bringezu F, Chang S, Dammann M, Frotschl R, et al.
Regul Toxicol Pharmacol
. 2018 Dec;
102:13-22.
PMID: 30572081
Recent updates of the OECD Guidelines for the Testing of Chemicals (Section 4: Health Effects) on genotoxicity testing emphasize the use of appropriate statistical methods for data analysis and proficiency...
6.
Igl B, Dertinger S, Dobrovolsky V, Raschke M, Sutter A, Vonk R
Mutat Res Genet Toxicol Environ Mutagen
. 2018 Jun;
831:33-44.
PMID: 29875075
The in vivo Pig-a gene mutation assay serves to evaluate the genotoxic potential of chemicals. In the rat blood-based assay, the lack of CD59 on the surface of erythrocytes is...
7.
Ruppert S, Vormberge T, Igl B, Hoffmann M
J Pharmacol Toxicol Methods
. 2016 Apr;
81:88-98.
PMID: 27118261
Introduction: During preclinical drug development, monitoring of the electrocardiogram (ECG) is an important part of cardiac safety assessment. To detect potential pro-arrhythmic liabilities of a drug candidate and for internal...
8.
Prelle K, Igl B, Obendorf M, Girbig D, Lehmann T, Patchev V
Menopause
. 2012 Apr;
19(8):909-15.
PMID: 22473248
Objective: Estrogen supplementation is considered a reliable therapeutic approach to symptoms of vasomotor dysregulation (hot flashes) associated with the menopausal transition and sex hormone deprivation. Implication of changes in central...
9.
Girbig D, Keller K, Prelle K, Patchev V, Vonk R, Igl B
J Circadian Rhythms
. 2012 Jan;
10(1):1.
PMID: 22221596
Menopause-associated thermoregulatory dysfunction can lead to symptoms such as hot flushes severely impairing quality of life of affected women. Treatment effects are often assessed by the ovariectomized rat model providing...
10.
Gemoll T, Roblick U, Szymczak S, Braunschweig T, Becker S, Igl B, et al.
Cell Mol Life Sci
. 2011 Feb;
68(19):3261-74.
PMID: 21290163
DNA aneuploidy has been identified as a prognostic factor for epithelial malignancies. Further understanding of the translation of DNA aneuploidy into protein expression will help to define novel biomarkers to...