Bernard T Golding
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Explore the profile of Bernard T Golding including associated specialties, affiliations and a list of published articles.
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133
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1461
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Recent Articles
1.
Tromans J, Zhang B, Golding B
Org Biomol Chem
. 2024 Sep;
22(39):7989-7995.
PMID: 39233652
Plasmalogens are glycerophospholipids distinguished by their -()-vinyl ether at the -1 position. These lipids are implicated in several disease states requiring analytical, diagnostic and therapeutic interventions, which demand synthetic availability...
2.
Mori K, Golding B, Toraya T
J Biochem
. 2024 Jul;
176(3):245-254.
PMID: 38987935
3,3,3-Trifluoro-1,2-propanediol undergoes complete defluorination in two distinct steps: first, the conversion into 3,3,3-trifluoropropionaldehyde catalyzed by adenosylcobalamin (coenzyme B12)-dependent diol dehydratase; second, non-enzymatic elimination of all three fluorides from this aldehyde...
3.
Tromans J, Zhang B, Golding B
Chem Commun (Camb)
. 2023 Oct;
59(89):13333-13335.
PMID: 37867450
A new benzyl-type protecting group (1,4-dimethoxynaphthalene-2-methyl, 'DIMON') for hydroxyl functions can be selectively removed under oxidative conditions without damaging polyunsaturated fatty acyl groups. Its application is shown by the first...
4.
Tromans J, Zhang B, Golding B
Chemistry
. 2023 Sep;
30(2):e202302708.
PMID: 37732540
Vinyl ethers are valuable synthetic intermediates which are also found as natural products, including aflatoxins, rifamycins and plasmalogens. The latter are ubiquitous phospholipids in human cells and contain a vinyl...
5.
Watson W, Munter T, Golding B
Chem Biol Interact
. 2023 Jun;
382:110591.
PMID: 37302460
Vitamin B (cyano- or hydroxo-cobalamin) acts, via its coenzymes, methyl- and adenosyl-cobalamin, as a partner for enzymatic reactions in humans catalysed by methionine synthase and methylmalonyl-CoA mutase. As well as...
6.
Uguen M, Davison G, Sprenger L, Hunter J, Martin M, Turberville S, et al.
J Med Chem
. 2022 Aug;
65(16):11322-11339.
PMID: 35943172
High-throughput screening provides one of the most common ways of finding hit compounds. Lead-like libraries, in particular, provide hits with compatible functional groups and vectors for structural elaboration and physical...
7.
Golding B, Abelairas-Edesa M, Tilbury R, Wilson J, Zhang D, Henderson A, et al.
Chem Biol Interact
. 2022 May;
361:109949.
PMID: 35490797
Reactions of the epoxides of 1,3-butadiene and isoprene (2-methyl-1,3-butadiene) with oxygen, nitrogen and sulfur nucleophiles have been compared to enable a better molecular understanding of the relative human toxicities of...
8.
Miller D, Reuillon T, Molyneux L, Blackburn T, Cook S, Edwards N, et al.
J Med Chem
. 2022 Apr;
65(9):6513-6540.
PMID: 35468293
The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approach...
9.
Picazo E, Heptinstall A, Wilson D, Cano C, Golding B, Waring M
J Heterocycl Chem
. 2021 Nov;
58(4):947-951.
PMID: 34824482
Substituted aminopyrimidines are an important class of compounds, in part because they frequently show biological activity. Facile synthesis of polysubstituted aminopyrimidines is highly desirable for the synthesis of screening libraries....
10.
Al-Khawaldeh I, Al Yasiri M, Aldred G, Basmadjian C, Bordoni C, Harnor S, et al.
J Med Chem
. 2021 Jul;
64(14):10001-10018.
PMID: 34212719
NF-κB-inducing kinase (NIK) is a key enzyme in the noncanonical NF-κB pathway, of interest in the treatment of a variety of diseases including cancer. Validation of NIK as a drug...