Bernard L Mirkin
Overview
Explore the profile of Bernard L Mirkin including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
294
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Recent Articles
1.
Smith D, Clark S, Bertin P, Mirkin B, Nguyen S
J Mater Chem
. 2014 Jan;
19(15):2159-2165.
PMID: 24421587
A new type of polymer nanoparticle (PNP) containing a high density of covalently linked doxorubicin, attached via a non-cleavable amine linkage (amine-linked Dox-PNP) was prepared. Together with a previously reported...
2.
Zhao R, Liang D, Li G, Larrimore C, Mirkin B
PLoS One
. 2010 Jul;
5(7):e11466.
PMID: 20628645
Several unique biological features of HIV-1 Vpr make it a potentially powerful agent for anti-cancer therapy. First, Vpr inhibits cell proliferation by induction of cell cycle G2 arrest. Second, it...
3.
Zheng X, Chu F, Chou P, Gallati C, Dier U, Mirkin B, et al.
Am J Physiol Cell Physiol
. 2008 Oct;
296(1):C65-74.
PMID: 18971393
Cathepsin L is a lysosomal enzyme thought to play a key role in malignant transformation. Recent work from our laboratory has demonstrated that this enzyme may also regulate cancer cell...
4.
Zheng X, Chu F, Mirkin B, Sudha T, Mousa S, Rebbaa A
Biochim Biophys Acta
. 2008 Sep;
1783(12):2294-300.
PMID: 18775751
The present investigation was undertaken to measure the relative abilities of pro-death versus pro-survival proteases in degrading each other and to determine how this might influence cellular susceptibility to death....
5.
Chu F, Chou P, Mirkin B, Mousa S, Rebbaa A
Aging Cell
. 2008 May;
7(4):516-25.
PMID: 18489729
Evidence is accumulating that chromatin plays a major role in the control of cellular response to stress. This is best illustrated by the recent findings that chromatin-modifying factors of class...
6.
Qiu Y, Mirkin B, Dwivedi R
Mol Cell Biochem
. 2007 Mar;
301(1-2):131-5.
PMID: 17387584
MDR1 hypermethylation plays an important role in pathogenesis and progression of neuroblastoma tumors. This hypothesis was tested by studying the methylation status of MDR1 gene promoter in neureoblastoma biopsy specimens...
7.
Chu F, Chou P, Zheng X, Mirkin B, Rebbaa A
Cancer Res
. 2005 Nov;
65(22):10183-7.
PMID: 16288004
Irreversible growth arrest (also called senescence) has emerged recently as a tumor suppressor mechanism and a key determinant of cancer chemotherapy outcome. Previous work from our laboratory suggested that the...
8.
Qiu Y, Mirkin B, Dwivedi R
Cancer Detect Prev
. 2005 Sep;
29(5):456-63.
PMID: 16185816
Background: Acquired drug resistance is a major obstacle to the successful treatment of neuroblastoma by chemotherapy. Recent studies from our laboratory have demonstrated that drug-induced alterations in DNA methylation play...
9.
Mirkin B, Clark S, Zheng X, Chu F, White B, Greene M, et al.
Oncogene
. 2005 May;
24(31):4965-74.
PMID: 15897897
Resistance to cytotoxic agents is a major limitation for their clinical use to treat human cancers. Tumors become resistant to chemotherapy when a subset of cells undergoes molecular changes leading...
10.
Zheng X, Chou P, Mirkin B, Rebbaa A
Cancer Res
. 2004 Mar;
64(5):1773-80.
PMID: 14996739
The present study was undertaken to verify whether induction of senescence could be sufficient to reverse drug resistance and, if so, to determine the underlying mechanism(s). Our findings indicated that...