Benjamin Pardo
Overview
Explore the profile of Benjamin Pardo including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
515
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0
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Recent Articles
1.
Ovejero S, Kumanski S, Soulet C, Azarli J, Pardo B, Santt O, et al.
EMBO J
. 2023 Jun;
42(15):e112684.
PMID: 37303233
Upon DNA damage, cells activate the DNA damage response (DDR) to coordinate proliferation and DNA repair. Dietary, metabolic, and environmental inputs are emerging as modulators of how DNA surveillance and...
2.
Reusswig K, Bittmann J, Peritore M, Courtes M, Pardo B, Wierer M, et al.
Nat Commun
. 2022 Nov;
13(1):7014.
PMID: 36400763
DNA replicates once per cell cycle. Interfering with the regulation of DNA replication initiation generates genome instability through over-replication and has been linked to early stages of cancer development. Here,...
3.
Pourali P, Pasero P, Pardo B
MicroPubl Biol
. 2022 Jan;
2022.
PMID: 35071999
Camptothecin (CPT) is a specific inhibitor of the DNA topoisomerase I (Top1p), currently used in cancer therapy, which induces DNA damage and cell death. Top1p is highly active at the...
4.
Voordeckers K, Colding C, Grasso L, Pardo B, Hoes L, Kominek J, et al.
Nat Commun
. 2020 Jul;
11(1):3664.
PMID: 32694532
Ethanol is a ubiquitous environmental stressor that is toxic to all lifeforms. Here, we use the model eukaryote Saccharomyces cerevisiae to show that exposure to sublethal ethanol concentrations causes DNA...
5.
Pardo B, Moriel-Carretero M, Vicat T, Aguilera A, Pasero P
EMBO Rep
. 2020 May;
21(7):e49367.
PMID: 32419301
Impediments to DNA replication threaten genome stability. The homologous recombination (HR) pathway has been involved in the restart of blocked replication forks. Here, we used a method to increase yeast...
6.
Forey R, Poveda A, Sharma S, Barthe A, Padioleau I, Renard C, et al.
Mol Cell
. 2020 Mar;
78(3):396-410.e4.
PMID: 32169162
The Mec1 and Rad53 kinases play a central role during acute replication stress in budding yeast. They are also essential for viability in normal growth conditions, but the signal that...
7.
Zhu Y, Biernacka A, Pardo B, Dojer N, Forey R, Skrzypczak M, et al.
Nat Commun
. 2019 May;
10(1):2313.
PMID: 31127121
DNA double-strand breaks (DSBs) are among the most lethal types of DNA damage and frequently cause genome instability. Sequencing-based methods for mapping DSBs have been developed but they allow measurement...
8.
Moriel-Carretero M, Pasero P, Pardo B
Curr Genet
. 2018 Nov;
65(2):445-451.
PMID: 30467717
Eukaryotic cells activate cell cycle checkpoints in response to DNA damage. In Saccharomyces cerevisiae, the DNA damage response is achieved by the activation of the sensor kinases Mec1 and Tel1...
9.
Biernacka A, Zhu Y, Skrzypczak M, Forey R, Pardo B, Grzelak M, et al.
Commun Biol
. 2018 Nov;
1:181.
PMID: 30393778
Maintenance of genome stability is a key issue for cell fate that could be compromised by chromosome deletions and translocations caused by DNA double-strand breaks (DSBs). Thus development of precise...
10.
Bacal J, Moriel-Carretero M, Pardo B, Barthe A, Sharma S, Chabes A, et al.
EMBO J
. 2018 Aug;
37(21).
PMID: 30158111
The S-phase checkpoint maintains the integrity of the genome in response to DNA replication stress. In budding yeast, this pathway is initiated by Mec1 and is amplified through the activation...