Benjamin P Martin
Overview
Explore the profile of Benjamin P Martin including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
19
Citations
499
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0
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Recent Articles
11.
Martin B, Vasilieva E, Dupureur C, Spilling C
Bioorg Med Chem
. 2015 Nov;
23(24):7529-34.
PMID: 26585276
New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. Surprisingly, the phosphate, phosphonate, and difluorophosphonate analogs all...
12.
Martin B, Brandon C, Stewart J, Braun-Sand S
Proteins
. 2015 May;
83(8):1427-35.
PMID: 25973843
Using the semiempirical method PM7, an attempt has been made to quantify the error in prediction of the in vivo structure of proteins relative to X-ray structures. Three important contributory...
13.
Vasilieva E, Dutta S, Malla R, Martin B, Spilling C, Dupureur C
Bioorg Med Chem
. 2015 Feb;
23(5):944-52.
PMID: 25678014
Cyclipostins are bicyclic lipophilic phosphate natural products. We report here that synthesized individual diastereomers of cyclipostins P and R have nanomolar IC50s toward hormone sensitive lipase (HSL). The less potent...
14.
Brandon C, Martin B, McGee K, Stewart J, Braun-Sand S
J Mol Model
. 2015 Jan;
21(1):3.
PMID: 25605595
An accurate model of three-dimensional protein structure is important in a variety of fields such as structure-based drug design and mechanistic studies of enzymatic reactions. While the entries in the...
15.
Shortt J, Hsu A, Martin B, Doggett K, Matthews G, Doyle M, et al.
Cell Rep
. 2014 May;
7(4):1009-19.
PMID: 24813887
N-methyl-2-pyrrolidone (NMP) is a common solvent and drug vehicle. We discovered unexpected antineoplastic and immunomodulatory activity of NMP in a cMYC-driven myeloma model. Coincident to this, NMP was identified as...
16.
Bots M, Verbrugge I, Martin B, Salmon J, Ghisi M, Baker A, et al.
Blood
. 2014 Jan;
123(9):1341-52.
PMID: 24415537
Epigenetic modifying enzymes such as histone deacetylases (HDACs), p300, and PRMT1 are recruited by AML1/ETO, the pathogenic protein for t(8;21) acute myeloid leukemia (AML), providing a strong molecular rationale for...
17.
Shortt J, Martin B, Newbold A, Hannan K, Devlin J, Baker A, et al.
Blood
. 2013 Feb;
121(15):2964-74.
PMID: 23403624
Pharmacological strategies capable of directly targeting MYC are elusive. Previous studies have shown that MYC-driven lymphomagenesis is associated with mammalian target of rapamycin (mTOR) activation and a MYC-evoked DNA damage...
18.
Point V, Malla R, Diomande S, Martin B, Delorme V, Carriere F, et al.
J Med Chem
. 2012 Oct;
55(22):10204-19.
PMID: 23095026
A new series of customizable diastereomeric cis- and trans-monocyclic enol-phosphonate analogs to Cyclophostin and Cyclipostins were synthesized. Their potencies and mechanisms of inhibition toward six representative lipolytic enzymes belonging to...
19.
Bishton M, Harrison S, Martin B, McLaughlin N, James C, Josefsson E, et al.
Blood
. 2011 Feb;
117(13):3658-68.
PMID: 21292776
Histone deacetylase inhibitor (HDACI)-induced thrombocytopenia (TCP) is a major dose-limiting toxicity of this new class of drugs. Using preclinical models to study the molecular and biologic events that underpin this...