Benjamin K Johnson
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Explore the profile of Benjamin K Johnson including associated specialties, affiliations and a list of published articles.
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Citations
859
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Recent Articles
1.
Dechow S, Goyal R, Johnson B, Haiderer E, Abramovitch R
Infect Immun
. 2025 Feb;
93(3):e0056824.
PMID: 39964175
The (Mtb) two-component regulatory system PhoPR is implicated in pH sensing within the macrophage because it is strongly induced by acidic pH both and the macrophage phagosome. The carbonic anhydrase...
2.
Dutcher J, Schmidt W, Doshi H, Johnson B, Sander P, Subramanian S
JACC Cardiovasc Interv
. 2024 Dec;
17(23):2848-2849.
PMID: 39663071
No abstract available.
3.
Jang H, Urrutia G, Orskov A, Kim H, Nelson S, Nguyen A, et al.
bioRxiv
. 2024 Nov;
PMID: 39605731
Almost 50% of patients with myelodysplastic syndrome (MDS) are refractory to first-line hypomethylating agents (HMAs), which presents a significant clinical challenge considering the lack of options for salvage. Past work...
4.
Oswald B, DeCamp L, Longo J, Dahabieh M, Bunda N, Ma S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605550
Reducing calorie intake without malnutrition limits tumor progression but the underlying mechanisms are poorly understood. Here we show that dietary restriction (DR) suppresses tumor growth by enhancing CD8 T cell-mediated...
5.
Sundaram L, Kumar A, Zatzman M, Salcedo A, Ravindra N, Shams S, et al.
Science
. 2024 Sep;
385(6713):eadk9217.
PMID: 39236169
To identify cancer-associated gene regulatory changes, we generated single-cell chromatin accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas. Tumor chromatin accessibility is strongly influenced by...
6.
Kaymak I, Watson M, Oswald B, Ma S, Johnson B, DeCamp L, et al.
J Exp Med
. 2024 Aug;
221(9).
PMID: 39150482
Coordination of cellular metabolism is essential for optimal T cell responses. Here, we identify cytosolic acetyl-CoA production as an essential metabolic node for CD8 T cell function in vivo. We...
7.
Zhou W, Johnson B, Morrison J, Beddows I, Eapen J, Katsman E, et al.
Nucleic Acids Res
. 2024 Feb;
52(6):e32.
PMID: 38412294
Data from both bulk and single-cell whole-genome DNA methylation experiments are under-utilized in many ways. This is attributable to inefficient mapping of methylation sequencing reads, routinely discarded genetic information, and...
8.
Morrison J, Zhou W, Johnson B, Shen H
Bioinformatics
. 2023 Dec;
39(12).
PMID: 38092060
Summary: In whole genome sequencing data, polymerase chain reaction amplification results in duplicate DNA fragments coming from the same location in the genome. The process of preparing a whole genome...
9.
Beddows I, Fan H, Heinze K, Johnson B, Leonova A, Senz J, et al.
Cancer Res
. 2023 Oct;
84(1):26-38.
PMID: 37874327
Significance: Two cancer histotypes diverge from a common cell of origin epigenetically locked in different cell states, highlighting the importance of considering cell state to better understand the cell of...
10.
Yang D, Beddows I, Tang H, Cascio S, McGonigal S, Bai S, et al.
bioRxiv
. 2023 Jul;
PMID: 37461447
Statement Of Significance: We developed a tumor model with human stromal, vascular, and immune cells. This model mirrors patient response to chemotherapy, targeted therapy, and immunotherapy, and can be used...