Benjamin Descours
Overview
Explore the profile of Benjamin Descours including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1636
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0
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Recent Articles
1.
Wang C, Thanh C, Gibson E, Ball-Burack M, Hogan L, Descours B, et al.
Blood Adv
. 2018 Dec;
2(23):3479-3482.
PMID: 30530753
No abstract available.
2.
Descours B, Petitjean G, Benkirane M
Nature
. 2018 Sep;
561(7723):E29.
PMID: 30232426
No abstract available.
3.
Descours B, Petitjean G, Lopez-Zaragoza J, Bruel T, Raffel R, Psomas C, et al.
Nature
. 2017 Jun;
546(7660):686.
PMID: 28658234
This corrects the article DOI: 10.1038/nature21710.
4.
Descours B, Petitjean G, Lopez-Zaragoza J, Bruel T, Raffel R, Psomas C, et al.
Nature
. 2017 Mar;
543(7646):564-567.
PMID: 28297712
The persistence of the HIV reservoir in infected individuals is a major obstacle to the development of a cure for HIV. Here, using an in vitro model of HIV-infected quiescent...
5.
Samri A, Bacchus-Souffan C, Hocqueloux L, Avettand-Fenoel V, Descours B, Theodorou I, et al.
AIDS
. 2016 Jul;
30(15):2299-302.
PMID: 27428742
To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality...
6.
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle
Coiras M, Bermejo M, Descours B, Mateos E, Garcia-Perez J, Lopez-Huertas M, et al.
Cell Rep
. 2016 Mar;
14(9):2100-2107.
PMID: 26923586
HIV-1 post-integration latency in CD4+ lymphocytes is responsible for viral persistence despite treatment, but mechanisms involved in the establishment of latent viral reservoirs are not fully understood. We determined that...
7.
Bermejo M, Lopez-Huertas M, Garcia-Perez J, Climent N, Descours B, Ambrosioni J, et al.
Biochem Pharmacol
. 2016 Feb;
106:30-45.
PMID: 26851491
Massive activation of infected CD4+ T cells during acute HIV-1 infection leads to reservoir seeding and T-cell destruction. During T-cell activation, the antiviral effect of the innate factor SAMHD1 is...
8.
de Masson A, Kirilovsky A, Zoorob R, Avettand-Fenoel V, Morin V, Oudin A, et al.
AIDS
. 2014 May;
28(11):1567-77.
PMID: 24804861
Objectives: The aim of the study was to determine the molecular mechanisms underlying the quasi-equilibrium between HIV and its host in the model of functional cure represented by elite controllers...
9.
Cribier A, Descours B, Chaves Valadao A, Laguette N, Benkirane M
Cell Rep
. 2013 Apr;
3(4):1036-43.
PMID: 23602554
SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4(+) T cells. Here, we show that SAMHD1 restriction activity is regulated by phosphorylation. SAMHD1 interacts with cyclin A2/cdk1 only in cycling...
10.
Saez-Cirion A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, et al.
PLoS Pathog
. 2013 Mar;
9(3):e1003211.
PMID: 23516360
Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a...