Benjamin D Umans
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Explore the profile of Benjamin D Umans including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
1027
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Recent Articles
1.
Umans B, Gilad Y
bioRxiv
. 2024 Sep;
PMID: 39282424
The interaction between genetic variants and environmental stressors is key to understanding the mechanisms underlying neurological diseases. In this study, we used human brain organoids to explore how varying oxygen...
2.
Yang D, Almanzar N, Xia J, Udit S, Yeung S, Khairallah C, et al.
bioRxiv
. 2024 Sep;
PMID: 39229208
Influenza viruses are a major global cause of morbidity and mortality. Vagal TRPV1 nociceptive sensory neurons, which innervate the airways, are known to mediate defenses against harmful agents. However, their...
3.
Umans B, Battle A, Gilad Y
Trends Genet
. 2020 Sep;
37(2):109-124.
PMID: 32912663
Most disease-associated variants, although located in putatively regulatory regions, do not have detectable effects on gene expression. One explanation could be that we have not examined gene expression in the...
4.
Prescott S, Umans B, Williams E, Brust R, Liberles S
Cell
. 2020 Apr;
181(3):574-589.e14.
PMID: 32259485
Sensory neurons initiate defensive reflexes that ensure airway integrity. Dysfunction of laryngeal neurons is life-threatening, causing pulmonary aspiration, dysphagia, and choking, yet relevant sensory pathways remain poorly understood. Here, we...
5.
Umans B, Liberles S
Trends Neurosci
. 2018 Aug;
41(12):911-924.
PMID: 30143276
Many internal organs change volume periodically. For example, the stomach accommodates ingested food and drink, the bladder stores urine, the heart fills with blood, and the lungs expand with every...
6.
Weaver A, Murphy S, Umans B, Tallavajhala S, Onyekwere I, Wittels S, et al.
Antimicrob Agents Chemother
. 2018 Aug;
62(10).
PMID: 30061291
Many bacteria are resistant to killing (tolerant) by typically bactericidal antibiotics due to their ability to counteract drug-induced cell damage. , the cholera agent, displays an unusually high tolerance to...
7.
Baral P, Umans B, Li L, Wallrapp A, Bist M, Kirschbaum T, et al.
Nat Med
. 2018 Jul;
24(10):1625-1626.
PMID: 30013196
In the version of this article initially published, the line graph showing TNF-α levels in Fig. 2d was inadvertently duplicated. A graph of IL-6 levels should be shown in place...
8.
Baral P, Umans B, Li L, Wallrapp A, Bist M, Kirschbaum T, et al.
Nat Med
. 2018 Mar;
24(4):417-426.
PMID: 29505031
Lung-innervating nociceptor sensory neurons detect noxious or harmful stimuli and consequently protect organisms by mediating coughing, pain, and bronchoconstriction. However, the role of sensory neurons in pulmonary host defense is...
9.
Williams E, Chang R, Strochlic D, Umans B, Lowell B, Liberles S
Cell
. 2016 May;
166(1):209-21.
PMID: 27238020
Neural inputs from internal organs are essential for normal autonomic function. The vagus nerve is a key body-brain connection that monitors the digestive, cardiovascular, and respiratory systems. Within the gastrointestinal...
10.
Dorr T, Delgado F, Umans B, Gerding M, Davis B, Waldor M
Antimicrob Agents Chemother
. 2016 May;
60(8):4757-63.
PMID: 27216069
Gram-negative bacteria are notoriously resistant to a variety of high-molecular-weight antibiotics due to the limited permeability of their outer membrane (OM). The basis of OM barrier function and the genetic...