Benjamin D Sunkel
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Explore the profile of Benjamin D Sunkel including associated specialties, affiliations and a list of published articles.
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9
Citations
120
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Recent Articles
1.
Wang M, Sreenivas P, Sunkel B, Wang L, Ignatius M, Stanton B
NAR Cancer
. 2023 Jun;
5(3):zcad028.
PMID: 37325549
Rhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with a lack of precision therapy options for patients. We hypothesized that with a general paucity of known mutations in RMS, chromatin...
2.
Wang M, Sunkel B, Ray W, Stanton B
BMC Mol Cell Biol
. 2022 Jul;
23(1):35.
PMID: 35902807
In the past decade, we have seen the emergence of sequence-based methods to understand chromosome organization. With the confluence of in situ approaches to capture information on looping, topological domains,...
3.
Laubscher D, Gryder B, Sunkel B, Andresson T, Wachtel M, Das S, et al.
Nat Commun
. 2021 Nov;
12(1):6924.
PMID: 34836971
Rhabdomyosarcoma (RMS) is a pediatric malignancy of skeletal muscle lineage. The aggressive alveolar subtype is characterized by t(2;13) or t(1;13) translocations encoding for PAX3- or PAX7-FOXO1 chimeric transcription factors, respectively,...
4.
Popova L, Nagarajan P, Lovejoy C, Sunkel B, Gardner M, Wang M, et al.
Nucleic Acids Res
. 2021 Nov;
49(21):12136-12151.
PMID: 34788845
A central component of the epigenome is the pattern of histone post-translational modifications that play a critical role in the formation of specific chromatin states. Following DNA replication, nascent chromatin...
5.
Sunkel B, Stanton B
iScience
. 2021 Oct;
24(10):103132.
PMID: 34632331
Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed...
6.
Wang L, Hensch N, Bondra K, Sreenivas P, Zhao X, Chen J, et al.
Cancer Res
. 2021 Aug;
81(21):5451-5463.
PMID: 34462275
Ionizing radiation (IR) and chemotherapy are mainstays of treatment for patients with rhabdomyosarcoma, yet the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor...
7.
Sunkel B, Wang M, LaHaye S, Kelly B, Fitch J, Barr F, et al.
iScience
. 2021 Aug;
24(8):102867.
PMID: 34386729
Recent characterizations of pioneer transcription factors provide insights into their structures and patterns of chromatin recognition associated with their roles in cell fate commitment and transformation. Intersecting with these basic...
8.
Boone M, Taslim C, Crow J, Selich-Anderson J, Byrum A, Showpnil I, et al.
Oncogene
. 2021 Jun;
40(29):4759-4769.
PMID: 34145397
Ewing sarcoma is an aggressive bone cancer of children and young adults defined by the presence of a chromosomal translocation: t(11;22)(q24;q12). The encoded protein, EWS/FLI, fuses the amino-terminal domain of...
9.
Narayanasamy S, Sun J, Pavlovicz R, Eroglu A, Rush C, Sunkel B, et al.
J Lipid Res
. 2017 Mar;
58(5):1021-1029.
PMID: 28250025
Consumption of the tomato carotenoid, lycopene, has been associated with favorable health benefits. Some of lycopene's biological activity may be due to metabolites resulting from cleavage of the lycopene molecule....