Benjamin Chagot
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Explore the profile of Benjamin Chagot including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
483
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Recent Articles
1.
Scat S, Weissman K, Chagot B
RSC Chem Biol
. 2024 Jul;
5(7):669-683.
PMID: 38966669
The fidelity of biosynthesis by modular polyketide synthases (PKSs) depends on specific moderate affinity interactions between successive polypeptide subunits mediated by docking domains (DDs). These sequence elements are notably portable,...
2.
Collin S, Cox R, Paris C, Jacob C, Chagot B, Weissman K, et al.
Nat Commun
. 2023 Mar;
14(1):1327.
PMID: 36899003
During biosynthesis by multi-modular trans-AT polyketide synthases, polyketide structural space can be expanded by conversion of initially-formed electrophilic β-ketones into β-alkyl groups. These multi-step transformations are catalysed by 3-hydroxy-3-methylgluratryl synthase...
3.
Risser F, Collin S, Dos Santos-Morais R, Gruez A, Chagot B, Weissman K
J Struct Biol
. 2020 Jul;
212(1):107581.
PMID: 32717326
Modular polyketide synthases (PKSs) are molecular-scale assembly lines comprising multiple gigantic polypeptide subunits. Faithful ordering of the subunits is mediated by extreme C- and N-terminal regions called docking domains (DDs)....
4.
Dorival J, Risser F, Jacob C, Collin S, Drager G, Paris C, et al.
Nat Commun
. 2020 Jan;
11(1):683.
PMID: 31996686
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
5.
Dorival J, Risser F, Jacob C, Collin S, Drager G, Paris C, et al.
Nat Commun
. 2019 Jan;
10(1):553.
PMID: 30696828
In the original version of this Article, the final concentration of riboflavin in the supplemented LB medium for recombinant LkcE expression was incorrectly stated as 1 g L (this was...
6.
Dorival J, Risser F, Jacob C, Collin S, Drager G, Paris C, et al.
Nat Commun
. 2018 Sep;
9(1):3998.
PMID: 30266997
Acquisition of new catalytic activity is a relatively rare evolutionary event. A striking example appears in the pathway to the antibiotic lankacidin, as a monoamine oxidase (MAO) family member, LkcE,...
7.
Shah V, Chagot B, Chazin W
Calcium Bind Proteins
. 2017 Aug;
1(4):203-212.
PMID: 28757812
Calcium plays an important role in regulating hundreds of biological processes due to its primary role as one of the most ubiquitous second messengers. As a result, the levels of...
8.
Dorival J, Annaval T, Risser F, Collin S, Roblin P, Jacob C, et al.
J Am Chem Soc
. 2016 Mar;
138(12):4155-67.
PMID: 26982529
Modular polyketide synthases (PKSs) direct the biosynthesis of clinically valuable secondary metabolites in bacteria. The fidelity of chain growth depends on specific recognition between successive subunits in each assembly line:...
9.
Langlois C, Ramboarina S, Cukkemane A, Auzat I, Chagot B, Gilquin B, et al.
J Biol Chem
. 2014 Dec;
290(6):3836-49.
PMID: 25525268
The majority of known bacteriophages have long tails that serve for bacterial target recognition and viral DNA delivery into the host. These structures form a tube from the viral capsid...
10.
Wells C, Bhaskara S, Stengel K, Zhao Y, Sirbu B, Chagot B, et al.
PLoS One
. 2013 Jul;
8(7):e68915.
PMID: 23894374
Given the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being...