Benjamin C Giglio
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Explore the profile of Benjamin C Giglio including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
54
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Recent Articles
1.
Oldan J, Giglio B, Smith E, Zhao W, Bouchard D, Ivanovic M, et al.
Oncoimmunology
. 2023 May;
12(1):2204753.
PMID: 37123046
Clinical trials of combined IDO/PD1 blockade in metastatic melanoma (MM) failed to show additional clinical benefit compared to PD1-alone inhibition. We reasoned that a tryptophan-metabolizing pathway other than the kynurenine...
2.
Giglio B, Wang H, Yan X, Li Z
Medchemcomm
. 2019 Jun;
10(5):814-816.
PMID: 31191872
A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT). An enzyme based assay demonstrated that 5-I-AMT is a substrate of IDO-1. The distribution and imaging potential of 5-I-AMT were...
3.
Giglio B, Fei H, Wang M, Wang H, He L, Feng H, et al.
Theranostics
. 2017 May;
7(6):1524-1530.
PMID: 28529635
Indoleamine 2,3-dioxygenase (IDO1) plays a special role in the biology of various cancer types, because it breaks down the essential amino acid tryptophan for immune cell activation. Upregulation of IDO1...
4.
Zhou B, Wang H, Liu R, Wang M, Deng H, Giglio B, et al.
Mol Pharm
. 2015 Aug;
12(10):3527-34.
PMID: 26288060
Delta-like ligand 4 (Dll4) expressed in tumor cells plays a key role to promote tumor growth of numerous cancer types. Based on a novel antihuman Dll4 monoclonal antibody (61B), we...
5.
Giglio B, Alexanian E
Org Lett
. 2014 Jul;
16(16):4304-7.
PMID: 25068635
A radical-mediated approach to alkene hydration is described. The present strategy capitalizes on the unique radical reactivity of hydroxamic acids, which are capable of functioning as both synthetically useful oxygen-centered...
6.
Giglio B, Schmidt V, Alexanian E
J Am Chem Soc
. 2011 Aug;
133(34):13320-2.
PMID: 21809867
The dioxygenation of alkenes using molecular oxygen and a simple hydroxamic acid derivative has been achieved. The reaction system consists of readily prepared methyl N-hydroxy-N-phenylcarbamate and molecular oxygen with a...
7.
Gupton J, Telang N, Banner E, Kluball E, Hall K, Finzel K, et al.
Tetrahedron
. 2010 Dec;
66(47):9113-9122.
PMID: 21135918
Studies directed at the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones from (Z)-3-aryl-3-haloenoic acids are described. The successful strategy relies on the preparation of (Z)-3-aryl-3-haloenoic acids from acetophenones through the corresponding (Z)-3-aryl-3-haloenals and the...
8.
Gupton J, Telang N, Jia X, Giglio B, Eaton J, Barelli P, et al.
Tetrahedron
. 2010 Nov;
66(44):8485-8493.
PMID: 21113324
Studies directed at the amine exchange reaction of vinamidinium salts followed by sodium borohydride reduction to secondary and tertiary allylic amines are described. The tertiary allylic amines were alkylated and...
9.
Gupton J, Giglio B, Eaton J, Rieck E, Smith K, Keough M, et al.
Tetrahedron
. 2010 Feb;
65(22):4283-4292.
PMID: 20161334
Studies directed at the synthesis of lamellarin G trimethyl ether and ningalin B via vinylogous iminium salt derivatives are described. The successful strategy relies on the formation of a 2,4-disubstituted...