Benjamin Basanta
Overview
Explore the profile of Benjamin Basanta including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
493
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Recent Articles
1.
Basanta B, Nugroho K, Yan N, Kline G, Powers E, Tsai F, et al.
Nat Struct Mol Biol
. 2025 Jan;
PMID: 39843982
Transthyretin (TTR) is a natively tetrameric thyroxine transporter in blood and cerebrospinal fluid whose misfolding and aggregation causes TTR amyloidosis. A rational drug design campaign identified the small molecule tafamidis...
2.
Chan L, Courteau B, Maker A, Wu M, Basanta B, Mehmood H, et al.
J Struct Biol
. 2024 Jun;
216(3):108108.
PMID: 38944401
Developments in direct electron detector technology have played a pivotal role in enabling high-resolution structural studies by cryo-EM at 200 and 300 keV. Yet, theory and recent experiments indicate advantages...
3.
Chan L, Courteau B, Maker A, Wu M, Basanta B, Mehmood H, et al.
bioRxiv
. 2024 Feb;
PMID: 38405886
Developments in direct electron detector technology have played a pivotal role in enabling high-resolution structural studies by cryo-EM at 200 and 300 keV. Yet, theory and recent experiments indicate advantages...
4.
Basanta B, Nugroho K, Yan N, Kline G, Powers E, Tsai F, et al.
bioRxiv
. 2024 Feb;
PMID: 38328110
Transthyretin (TTR) is a natively tetrameric thyroxine transporter found in blood and cerebrospinal fluid whose misfolding and aggregation causes transthyretin amyloidosis. A rational drug design campaign identified the small molecule...
5.
Basanta B, Chen W, Pride D, Lander G
J Vis Exp
. 2023 Sep;
(199).
PMID: 37747197
Cryogenic electron microscopy (cryoEM) has emerged as a powerful technique for probing the atomic structure of macromolecular complexes. Sample preparation for cryoEM requires preserving specimens in a thin layer of...
6.
Kipnis Y, Chaib A, Vorobieva A, Cai G, Reggiano G, Basanta B, et al.
Protein Sci
. 2022 Oct;
31(11):e4405.
PMID: 36305767
While native scaffolds offer a large diversity of shapes and topologies for enzyme engineering, their often unpredictable behavior in response to sequence modification makes de novo generated scaffolds an exciting...
7.
Basanta B, Hirschi M, Grotjahn D, Lander G
Acta Crystallogr D Struct Biol
. 2022 Jan;
78(Pt 1):124-135.
PMID: 34981768
Buffer-composition and sample-preparation guidelines for cryo-electron microscopy are geared towards maximizing imaging contrast and reducing electron-beam-induced motion. These pursuits often involve the minimization or the complete removal of additives that...
8.
Kisiela D, Magala P, Interlandi G, Carlucci L, Ramos A, Tchesnokova V, et al.
PLoS Pathog
. 2021 Apr;
17(4):e1009440.
PMID: 33826682
Critical molecular events that control conformational transitions in most allosteric proteins are ill-defined. The mannose-specific FimH protein of Escherichia coli is a prototypic bacterial adhesin that switches from an 'inactive'...
9.
Basanta B, Chowdhury S, Lander G, Grotjahn D
J Struct Biol X
. 2020 Dec;
4:100041.
PMID: 33319208
No abstract available.
10.
Barone F, Dorr F, Marasco L, Mildiner S, Patop I, Sosa S, et al.
Synth Biol (Oxf)
. 2020 Sep;
2(1):ysx006.
PMID: 32995507
The diversity and flexibility of life offers a wide variety of molecules and systems useful for biosensing. A biosensor device should be robust, specific and reliable. Inorganic arsenic is a...