Danielle A Grotjahn
Overview
Explore the profile of Danielle A Grotjahn including associated specialties, affiliations and a list of published articles.
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17
Citations
150
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Recent Articles
1.
Chang Y, Barad B, Hamid J, Rahmani H, Zid B, Grotjahn D
J Cell Biol
. 2025 Mar;
224(4).
PMID: 40047641
Most of the mitochondria proteome is nuclear-encoded, synthesized by cytoplasmic ribosomes, and targeted to the mitochondria posttranslationally. However, a subset of mitochondrial-targeted proteins is imported co-translationally, although the molecular mechanisms...
2.
Baron K, Oviedo S, Krasny S, Zaman M, Aldakhlallah R, Bora P, et al.
Elife
. 2025 Feb;
13.
PMID: 39937095
Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically diverse diseases, including many neurodegenerative disorders. The integrated stress response (ISR) - comprising the...
3.
Chawla R, Tom J, Boyd T, Tu N, Bai T, Grotjahn D, et al.
Nat Commun
. 2024 Oct;
15(1):9258.
PMID: 39462120
The inorganic biopolymer polyphosphate (polyP) occurs in all domains of life and affects myriad cellular processes. A longstanding observation is polyP's frequent proximity to chromatin, and, in many bacteria, its...
4.
Dahmane S, Schexnaydre E, Zhang J, Rosendal E, Chotiwan N, Kumari Singh B, et al.
bioRxiv
. 2024 Oct;
PMID: 39416041
Flaviviruses replicate their genomes in replication organelles (ROs) formed as bud-like invaginations on the endoplasmic reticulum (ER) membrane, which also functions as the site for virion assembly. While this localization...
5.
Chang Y, Barad B, Rahmani H, Zid B, Grotjahn D
bioRxiv
. 2024 Jul;
PMID: 39071314
Most of the mitochondria proteome is nuclear-encoded, synthesized by cytoplasmic ribosomes, and targeted to mitochondria post-translationally. However, a subset of mitochondrial-targeted proteins is imported co-translationally, although the molecular mechanisms governing...
6.
Baron K, Oviedo S, Krasny S, Zaman M, Aldakhlallah R, Bora P, et al.
bioRxiv
. 2024 Jun;
PMID: 38915623
Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically-diverse diseases, including many neurodegenerative disorders. The integrated stress response (ISR) - comprising the four...
7.
Mahalingan K, Grotjahn D, Li Y, Lander G, Zehr E, Roll-Mecak A
Nat Chem Biol
. 2024 Apr;
20(11):1493-1504.
PMID: 38658656
Microtubules have spatiotemporally complex posttranslational modification patterns. Tubulin tyrosine ligase-like (TTLL) enzymes introduce the most prevalent modifications on α-tubulin and β-tubulin. How TTLLs specialize for specific substrate recognition and ultimately...
8.
Newman L, Novak S, Rojas G, Tadepalle N, Schiavon C, Grotjahn D, et al.
Nat Cell Biol
. 2024 Feb;
26(2):194-206.
PMID: 38332353
Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm,...
9.
Aiyer S, Baldwin P, Tan S, Shan Z, Oh J, Mehrani A, et al.
Nat Commun
. 2024 Jan;
15(1):389.
PMID: 38195598
Structural biology efforts using cryogenic electron microscopy are frequently stifled by specimens adopting "preferred orientations" on grids, leading to anisotropic map resolution and impeding structure determination. Tilting the specimen stage...
10.
Chawla R, Tom J, Boyd T, Grotjahn D, Park D, Deniz A, et al.
bioRxiv
. 2023 Sep;
PMID: 37745474
The ancient, inorganic biopolymer polyphosphate (polyP) occurs in all three domains of life and affects myriad cellular processes. An intriguing feature of polyP is its frequent proximity to chromatin, and...