Benedikt Scheidecker
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Explore the profile of Benedikt Scheidecker including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
43
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Recent Articles
1.
Scheidecker B, Poulain S, Sugimoto M, Kido T, Kawanishi T, Miyajima A, et al.
Biofabrication
. 2024 Mar;
16(2).
PMID: 38447229
Availability of hepatic tissue for the investigation of metabolic processes is severely limited. While primary hepatocytes or animal models are widely used in pharmacological applications, a change in methodology towards...
2.
Scheidecker B, Poulain S, Sugimoto M, Arakawa H, Kim S, Kawanishi T, et al.
Biotechnol Bioeng
. 2024 Jan;
121(4):1435-1452.
PMID: 38184801
Hepatic physiology depends on the liver's complex structural composition which among others, provides high oxygen supply rates, locally differential oxygen tension, endothelial paracrine signaling, as well as residual hemodynamic shear...
3.
Danoy M, Poulain S, Jellali R, Scheidecker B, Tauran Y, Leduc M, et al.
Hepatol Res
. 2023 Mar;
53(7):661-674.
PMID: 36866738
Aim: Hepatic zonation is a physiological feature of the liver, known to be key in the regulation of the metabolism of nutrients and xenobiotics and the biotransformation of numerous substances....
4.
Nishikawa M, Ito H, Tokito F, Hirono K, Inamura K, Scheidecker B, et al.
Front Toxicol
. 2022 Jun;
4:810478.
PMID: 35733832
In the pharmaceutical industry, primary cultured hepatocytes is a standard tool used to assess hepatic metabolisms and toxicity . Drawbacks, however, include their functional deterioration upon isolation, mostly due to...
5.
Danoy M, Jellali R, Tauran Y, Bruce J, Leduc M, Gilard F, et al.
Differentiation
. 2021 Jul;
120:28-35.
PMID: 34229994
The liver is a complex organ composed of several cell types organized hierarchically. Among these, liver sinusoidal endothelial cells (LSECs) are specialized vascular cells known to interact with hepatocytes and...
6.
Essaouiba A, Jellali R, Shinohara M, Scheidecker B, Legallais C, Sakai Y, et al.
J Biotechnol
. 2021 Feb;
330:45-56.
PMID: 33617908
The limited availability of primary human β-cells/islets and their quality (due to donor diversity) restrict the development of in vitro models for diabetes research. Human induced pluripotent stem cells (hiPSCs)...
7.
Scheidecker B, Shinohara M, Sugimoto M, Danoy M, Nishikawa M, Sakai Y
Front Bioeng Biotechnol
. 2020 Jul;
8:524.
PMID: 32656187
Pre-clinical drug screening is an important step in assessing the metabolic effects and hepatic toxicity of new pharmaceutical compounds. However, due to the complexity of the liver microarchitecture, simplified models...
8.
Danoy M, Poulain S, Lereau-Bernier M, Kato S, Scheidecker B, Kido T, et al.
Biotechnol Prog
. 2020 May;
36(5):e3013.
PMID: 32364651
The liver zonation is an important phenomenon characterized by a gradient of several functions along the liver acinus. However, this gradient remains difficult to reproduce in in-vitro conditions, making the...
9.
Danoy M, Poulain S, Koui Y, Tauran Y, Scheidecker B, Kido T, et al.
Mol Omics
. 2020 Jan;
16(2):138-146.
PMID: 31989141
Liver Sinusoidal Endothelial Cells (LSECs) are an important component of the liver as they compose the microvasculature which allows the supply of oxygen, blood, and nutrients. However, maintenance of these...