Benedicte Michel
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Explore the profile of Benedicte Michel including associated specialties, affiliations and a list of published articles.
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40
Citations
1707
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Recent Articles
1.
Michel B, Sinha A, Leach D
Microbiol Mol Biol Rev
. 2018 Jun;
82(3).
PMID: 29898897
In all organisms, replication impairments are an important source of genome rearrangements, mainly because of the formation of double-stranded DNA (dsDNA) ends at inactivated replication forks. Three reactions for the...
2.
Sinha A, Possoz C, Durand A, Desfontaines J, Barre F, Leach D, et al.
PLoS Genet
. 2018 Mar;
14(3):e1007256.
PMID: 29522563
It was recently reported that the recBC mutants of Escherichia coli, deficient for DNA double-strand break (DSB) repair, have a decreased copy number of their terminus region. We previously showed...
3.
Sinha A, Durand A, Desfontaines J, Iurchenko I, Auger H, Leach D, et al.
PLoS Genet
. 2017 Oct;
13(10):e1006895.
PMID: 28968392
Marker frequency analysis of the Escherichia coli recB mutant chromosome has revealed a deficit of DNA in a specific zone of the terminus, centred on the dif/TerC region. Using fluorescence...
4.
Michel B, Sinha A
Mol Microbiol
. 2017 Mar;
104(6):1008-1026.
PMID: 28342235
The Escherichia coli holD mutant is poorly viable because the stability of holoenzyme polymerase III (Pol III HE) on DNA is compromised. Consequently, the SOS response is induced and the...
5.
Michel B, Sandler S
J Bacteriol
. 2017 Mar;
199(13).
PMID: 28320884
In bacteria, replication forks assembled at a replication origin travel to the terminus, often a few megabases away. They may encounter obstacles that trigger replisome disassembly, rendering replication restart from...
6.
Durand A, Sinha A, Dard-Dascot C, Michel B
PLoS Genet
. 2016 Jun;
12(6):e1006114.
PMID: 27280472
Mutants lacking the ψ (HolD) subunit of the Escherichia coli DNA Polymerase III holoenzyme (Pol III HE) have poor viability, but a residual growth allows the isolation of spontaneous suppressor...
7.
Klastersky J, Libert I, Michel B, Obiols M, Lossignol D
Support Care Cancer
. 2015 Oct;
24(4):1883-8.
PMID: 26466945
Supportive care in cancer has become a paradigm for the treatment in oncology. Now, we have guidelines and active research in that field, making this area of clinical oncology both...
8.
Michel B, Leach D
EcoSal Plus
. 2015 Oct;
5(1).
PMID: 26442826
Homologous recombination is an ubiquitous process that shapes genomes and repairs DNA damage. The reaction is classically divided into three phases: presynaptic, synaptic, and postsynaptic. In Escherichia coli, the presynaptic...
9.
Bentchikou E, Chagneau C, Long E, Matelot M, Allemand J, Michel B
PLoS One
. 2015 Aug;
10(8):e0134892.
PMID: 26244508
In all organisms several enzymes that are needed upon replication impediment are targeted to replication forks by interaction with a replication protein. In most cases these proteins interact with the...
10.
Duigou S, Silvain M, Viguera E, Michel B
PLoS Genet
. 2014 Oct;
10(10):e1004719.
PMID: 25329071
The HolC-HolD (χψ) complex is part of the DNA polymerase III holoenzyme (Pol III HE) clamp-loader. Several lines of evidence indicate that both leading- and lagging-strand synthesis are affected in...