Ben C Chung
Overview
Explore the profile of Ben C Chung including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
498
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0
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Recent Articles
1.
Huang C, Yu X, Fordstrom P, Choi K, Chung B, Roh S, et al.
Sci Adv
. 2020 Jun;
6(25):eabb1989.
PMID: 32596471
The intestinal absorption of cholesterol is mediated by a multipass membrane protein, Niemann-Pick C1-Like 1 (NPC1L1), the molecular target of a cholesterol lowering therapy ezetimibe. While ezetimibe gained Food and...
2.
Min X, Yie J, Wang J, Chung B, Huang C, Xu H, et al.
MAbs
. 2020 Jan;
12(1):1710047.
PMID: 31905038
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharmacological...
3.
Chung B, Mashalidis E, Tanino T, Kim M, Matsuda A, Hong J, et al.
Nature
. 2016 Apr;
533(7604):557-560.
PMID: 27088606
Antibiotic-resistant bacterial infection is a serious threat to public health. Peptidoglycan biosynthesis is a well-established target for antibiotic development. MraY (phospho-MurNAc-pentapeptide translocase) catalyses the first and an essential membrane step...
4.
Zubcevic L, Herzik Jr M, Chung B, Liu Z, Lander G, Lee S
Nat Struct Mol Biol
. 2016 Jan;
23(2):180-186.
PMID: 26779611
Transient receptor potential vanilloid (TRPV) cation channels are polymodal sensors involved in a variety of physiological processes. TRPV2, a member of the TRPV family, is regulated by temperature, by ligands,...
5.
Wang C, Chung B, Yan H, Wang H, Lee S, Pitt G
Nat Commun
. 2014 Sep;
5:4896.
PMID: 25232683
Ca(2+) regulates voltage-gated Na(+) (NaV) channels, and perturbed Ca(2+) regulation of NaV function is associated with epilepsy syndromes, autism and cardiac arrhythmias. Understanding the disease mechanisms, however, has been hindered...
6.
Chung B, Zhao J, Gillespie R, Kwon D, Guan Z, Hong J, et al.
Science
. 2013 Aug;
341(6149):1012-1016.
PMID: 23990562
MraY (phospho-MurNAc-pentapeptide translocase) is an integral membrane enzyme that catalyzes an essential step of bacterial cell wall biosynthesis: the transfer of the peptidoglycan precursor phospho-MurNAc-pentapeptide to the lipid carrier undecaprenyl...
7.
Wang C, Chung B, Yan H, Lee S, Pitt G
Structure
. 2012 Jun;
20(7):1167-76.
PMID: 22705208
Voltage-gated Na⁺ (Na(V)) channels initiate neuronal action potentials. Na(V) channels are composed of a transmembrane domain responsible for voltage-dependent Na⁺ conduction and a cytosolic C-terminal domain (CTD) that regulates channel...