Bede Constantinides
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Explore the profile of Bede Constantinides including associated specialties, affiliations and a list of published articles.
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20
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1541
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Recent Articles
1.
Hunt M, Hinrichs A, Anderson D, Karim L, Dearlove B, Knaggs J, et al.
bioRxiv
. 2024 May;
PMID: 38746185
The SARS-CoV-2 genome occupies a unique place in infection biology - it is the most highly sequenced genome on earth (making up over 20% of public sequencing datasets) with fine...
2.
Constantinides B, Hunt M, Crook D
Bioinformatics
. 2023 Dec;
39(12).
PMID: 38039142
Motivation: Microbial sequences generated from clinical samples are often contaminated with human host sequences that must be removed for ethical and legal reasons. Care must be taken to excise host...
3.
Megremis S, Constantinides B, Xepapadaki P, Yap C, Sotiropoulos A, Bachert C, et al.
Sci Rep
. 2023 May;
13(1):8319.
PMID: 37221274
Asthma development and exacerbation is linked to respiratory virus infections. There is limited information regarding the presence of viruses during non-exacerbation/infection periods. We investigated the nasopharyngeal/nasal virome during a period...
4.
Taylor A, Tinning H, Ovchinnikov V, Edge J, Smith W, Pullinger A, et al.
Commun Biol
. 2023 Apr;
6(1):459.
PMID: 37100852
The origin of embryo implantation in mammals ~148 million years ago was a dramatic shift in reproductive strategy, yet the molecular changes that established mammal implantation are largely unknown. Although...
5.
Rovira Rubio J, Megremis S, Pasioti M, Lakoumentas J, Constantinides B, Xepapadaki P, et al.
Allergy
. 2023 Jan;
78(5):1258-1268.
PMID: 36595290
Background: From early life, respiratory viruses are implicated in the development, exacerbation and persistence of respiratory conditions such as asthma. Complex dynamics between microbial communities and host immune responses shape...
6.
Kotanidis C, Xie C, Alexander D, Rodrigues J, Burnham K, Mentzer A, et al.
Lancet Digit Health
. 2022 Aug;
4(10):e705-e716.
PMID: 36038496
Background: Direct evaluation of vascular inflammation in patients with COVID-19 would facilitate more efficient trials of new treatments and identify patients at risk of long-term complications who might respond to...
7.
Tuekprakhon A, Nutalai R, Dijokaite-Guraliuc A, Zhou D, Ginn H, Selvaraj M, et al.
Cell
. 2022 Jun;
185(14):2422-2433.e13.
PMID: 35772405
The Omicron lineage of SARS-CoV-2, which was first described in November 2021, spread rapidly to become globally dominant and has split into a number of sublineages. BA.1 dominated the initial...
8.
Nutalai R, Zhou D, Tuekprakhon A, Ginn H, Supasa P, Liu C, et al.
Cell
. 2022 Jun;
185(12):2116-2131.e18.
PMID: 35662412
Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD has slightly higher ACE2 affinity than BA.1 and slightly...
9.
Hunt M, Swann J, Constantinides B, Fowler P, Iqbal Z
Bioinformatics
. 2022 May;
38(12):3291-3293.
PMID: 35551365
Summary: Viral sequence data from clinical samples frequently contain contaminating human reads, which must be removed prior to sharing for legal and ethical reasons. To enable host read removal for...
10.
Dejnirattisai W, Huo J, Zhou D, Zahradnik J, Supasa P, Liu C, et al.
Cell
. 2022 Jan;
185(3):467-484.e15.
PMID: 35081335
On 24 November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titers of Omicron...