Bas Ponsioen
Overview
Explore the profile of Bas Ponsioen including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
2663
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Recent Articles
1.
Mertens S, Huismans M, Verissimo C, Ponsioen B, Overmeer R, Proost N, et al.
Cell Rep
. 2023 Mar;
42(4):112324.
PMID: 37000626
Patient-derived organoids (PDOs) are widely heralded as a drug-screening platform to develop new anti-cancer therapies. Here, we use a drug-repurposing library to screen PDOs of colorectal cancer (CRC) to identify...
2.
Chen J, Hug C, Reyes J, Tian C, Gerosa L, Frohlich F, et al.
Cell Rep
. 2023 Mar;
42(3):112252.
PMID: 36920903
Oncogene-induced senescence is a phenomenon in which aberrant oncogene expression causes non-transformed cells to enter a non-proliferative state. Cells undergoing oncogenic induction display phenotypic heterogeneity, with some cells senescing and...
3.
Bollen Y, Hageman J, van Leenen P, Derks L, Ponsioen B, Buissant des Amorie J, et al.
PLoS Biol
. 2022 Jan;
20(1):e3001527.
PMID: 35089911
CRISPR-associated nucleases are powerful tools for precise genome editing of model systems, including human organoids. Current methods describing fluorescent gene tagging in organoids rely on the generation of DNA double-strand...
4.
van der Linden F, Mahlandt E, Arts J, Beumer J, Puschhof J, de Man S, et al.
Nat Commun
. 2021 Dec;
12(1):7159.
PMID: 34887382
The most successful genetically encoded calcium indicators (GECIs) employ an intensity or ratiometric readout. Despite a large calcium-dependent change in fluorescence intensity, the quantification of calcium concentrations with GECIs is...
5.
Kempers L, van der Bijl I, van Stalborch A, Ponsioen B, Margadant C
STAR Protoc
. 2021 Sep;
2(3):100690.
PMID: 34557696
We describe an optimized, cost-effective, reproducible, and robust protocol to study sprouting angiogenesis in glass-bottom 96-well plates by confocal microscopy, ideal for screening of drug or shRNA libraries. Effective and...
6.
Bollen Y, Stelloo E, van Leenen P, van den Bos M, Ponsioen B, Lu B, et al.
Nat Genet
. 2021 Jul;
53(8):1187-1195.
PMID: 34211178
Central to tumor evolution is the generation of genetic diversity. However, the extent and patterns by which de novo karyotype alterations emerge and propagate within human tumors are not well...
7.
Ponsioen B, Post J, Buissant des Amorie J, Laskaris D, van Ineveld R, Kersten S, et al.
Nat Cell Biol
. 2021 Apr;
23(4):377-390.
PMID: 33795873
Direct targeting of the downstream mitogen-activated protein kinase (MAPK) pathway to suppress extracellular-regulated kinase (ERK) activation in KRAS and BRAF mutant colorectal cancer (CRC) has proven clinically unsuccessful, but promising...
8.
Blokzijl-Franke S, Ponsioen B, Schulte-Merker S, Herbomel P, Kissa K, Choorapoikayil S, et al.
Oncogene
. 2021 Mar;
40(15):2741-2755.
PMID: 33714985
Hematopoietic stem and progenitor cells (HSPCs) are multipotent cells giving rise to all blood lineages during life. HSPCs emerge from the ventral wall of the dorsal aorta (VDA) during a...
9.
Kuijt T, Lambers M, Weterings S, Ponsioen B, Bolhaqueiro A, Staijen D, et al.
Curr Biol
. 2020 Sep;
30(19):3862-3870.e6.
PMID: 32888483
Accurate chromosome segregation during cell division critically depends on error correction of chromosome-spindle interactions and the spindle assembly checkpoint (SAC) [1-3]. The kinase MPS1 is an essential regulator of both...
10.
Beumer J, Puschhof J, Bauza-Martinez J, Martinez-Silgado A, Elmentaite R, James K, et al.
Cell
. 2020 Aug;
182(4):1062-1064.
PMID: 32822568
No abstract available.