Bart A Ploeger
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Explore the profile of Bart A Ploeger including associated specialties, affiliations and a list of published articles.
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30
Citations
581
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Recent Articles
11.
Snelder N, Ploeger B, Luttringer O, Stanski D, Danhof M
Drug Metab Dispos
. 2014 Jun;
42(9):1367-78.
PMID: 24965813
A complicating factor in the translational pharmacology of sphingosine 1-phosphate agonists is that they exert their pharmacological effect through their respective phosphate metabolites, which are formed by the enzyme sphingosine...
12.
van Rijn-Bikker P, Snelder N, Ackaert O, Van Hest R, Ploeger B, van Montfrans G, et al.
Am J Hypertens
. 2013 Aug;
26(9):1103-13.
PMID: 23939415
Background: Cardiac and cerebrovascular events in hypertensive patients are related to specific features of the 24-hour diurnal blood pressure (BP) profile (i.e., daytime and nighttime BP, nocturnal dip (ND), and...
13.
van Rijn-Bikker P, Ackaert O, Snelder N, Van Hest R, Ploeger B, Koopmans R, et al.
Clin Pharmacokinet
. 2013 May;
52(9):793-803.
PMID: 23696281
Background And Objective: It is well recognized that many antihypertensive drugs exhibit large interindividual variability in effect and that this wide range of patient response to antihypertensive drugs is a...
14.
Bueters T, Ploeger B, Visser S
Drug Discov Today
. 2013 May;
18(17-18):853-62.
PMID: 23665277
Translational pharmacokinetic-pharmacodynamic (PKPD) modeling has been fully implemented at AstraZeneca's drug discovery unit for central nervous system and pain indications to facilitate timely progression of the right compound to clinical...
15.
Stringer F, Ploeger B, DeJongh J, Scott G, Urquhart R, Karim A, et al.
J Clin Pharmacol
. 2013 Feb;
53(3):256-63.
PMID: 23444281
Sipoglitazar is a peroxisome proliferator-activated receptor α, δ, and γ agonist. During phase I, a wide distribution of clearance between individuals was observed. Hypothesized to result from a polymorphism in...
16.
Malmborg J, Ploeger B
J Pharmacol Toxicol Methods
. 2013 Jan;
67(3):203-13.
PMID: 23280406
Introduction: Predicting the pharmacokinetics (PK) of prodrugs and their corresponding active drugs is challenging, as there are many variables to consider. Prodrug conversion characteristics in different tissues are generally measured,...
17.
Stevens J, Ploeger B, Hammarlund-Udenaes M, Osswald G, van der Graaf P, Danhof M, et al.
J Pharmacokinet Pharmacodyn
. 2012 Jul;
39(5):463-77.
PMID: 22791078
The aim of this investigation was to develop a mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model for the biological system prolactin response following a dopamine inhibition challenge using remoxipride as a paradigm compound....
18.
Stevens J, Ploeger B, van der Graaf P, Danhof M, de Lange E
Drug Metab Dispos
. 2011 Sep;
39(12):2275-82.
PMID: 21903866
Intranasal (IN) administration could be an attractive mode of delivery for drugs targeting the central nervous system, potentially providing a high bioavailability because of avoidance of a hepatic first-pass effect...
19.
van Erp N, Guchelaar H, Ploeger B, Romijn J, den Hartigh J, Gelderblom H
Eur J Endocrinol
. 2011 Jan;
164(4):621-6.
PMID: 21220434
Objective: The effects of mitotane on the pharmacokinetics (PK) of co-administered drugs are mostly unknown. The aim of the present study was to describe the effects of mitotane on the...
20.
van Erp N, Baker S, Zandvliet A, Ploeger B, den Hollander M, Chen Z, et al.
Cancer Chemother Pharmacol
. 2010 Jun;
67(3):695-703.
PMID: 20512335
Purpose: The drug label of sunitinib includes a warning for concomitant use of grapefruit juice (GJ) but clinical evidence for this drug interaction is lacking. The aim of this study...