Barry Zirkin
Overview
Explore the profile of Barry Zirkin including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
336
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Recent Articles
1.
Traore K, Zirkin B
Front Toxicol
. 2024 Feb;
6:1352294.
PMID: 38362108
Leydig cells isolated from the testis are able to sustain high levels of testosterone production , but only for up to 3 days. Such cells are valuable for addressing the...
2.
Goldberg E, Lishko P, Papadopoulos V, Zirkin B
Front Endocrinol (Lausanne)
. 2022 Aug;
13:984409.
PMID: 35957828
No abstract available.
3.
Traore K, More P, Adla A, Dogbey G, Papadopoulos V, Zirkin B
Toxicology
. 2021 Oct;
463:152985.
PMID: 34627990
Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer that is widely used in manufacturing. Previous studies have shown that mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of DEHP, has inhibitory effects on luteinizing...
4.
Chung J, Chen H, Zirkin B
Biol Reprod
. 2021 Aug;
105(5):1307-1316.
PMID: 34363387
Previous studies reported that, with aging, Leydig cell intracellular antioxidants are reduced in concentration and intracellular ROS levels increase, suggesting that oxidant/antioxidant imbalance may contribute to the reduced testosterone production...
5.
Fan J, Campioli E, Sottas C, Zirkin B, Papadopoulos V
J Endocr Soc
. 2020 Feb;
4(2):bvaa001.
PMID: 32099945
Although the role of translocator protein (TSPO) in cholesterol transport in steroid-synthesizing cells has been studied extensively, recent studies of TSPO genetic depletion have questioned its role. -Cre mice have...
6.
Robaire B, Eddy M, Goldberg E, Griswold M, Heckert L, McCarrey J, et al.
Andrology
. 2020 Jan;
8(4):820-824.
PMID: 31968155
Objective: To provide an overview of the history of the North American Testis Workshop (NATW), of its relationship to the American Society of Andrology (ASA), and of the publications that...
7.
Chung J, Chen H, Papadopoulos V, Zirkin B
Andrology
. 2019 Nov;
8(3):719-730.
PMID: 31738001
Background: Cholesterol import into the mitochondria of steroid-producing cells is the rate-determining step in steroidogenesis. Numerous studies have provided evidence that the cholesterol-binding translocator protein (18 kDa TSPO) plays an...
8.
Vom Steeg L, Attreed S, Zirkin B, Klein S
Cell Immunol
. 2019 Sep;
345:103988.
PMID: 31540670
The severity of influenza increases with age, with worse disease in aged males than females. Testosterone concentrations decline with age in males, which may impact influenza pathogenesis. Aged male mice...
9.
Chung J, Brown S, Chen H, Liu J, Papadopoulos V, Zirkin B
Biol Reprod
. 2019 Sep;
102(2):489-498.
PMID: 31504200
The Leydig cells of the mammalian testis produce testosterone (T) in response to luteinizing hormone (LH). In rats and men with reduced serum T levels, T replacement therapy (TRT) will...
10.
Zhou C, Zaman N, Li Y, Martinez-Arguelles D, Papadopoulos V, Zirkin B, et al.
Reprod Toxicol
. 2019 Jan;
85:19-25.
PMID: 30648648
Mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), is a plasticizer with endocrine disruptor activity that has been shown to stimulate basal steroid biosynthesis in Leydig cells. The...