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Barry Ellefsen

Explore the profile of Barry Ellefsen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 225
Followers 0
Related Specialties
Allergy & Immunology
Pathology
General Medicine
Top 10 Co-Authors
Drew Hannaman
Nirbhay Kumar
Dibyadyuti Datta
Alain Luxembourg
Connie S Schmaljohn
Lesley C Dupuy
Geetha P Bansal
Claire F Evans
Don Wilson
Sylvia van Drunen Littel-van den Hurk
Published In
Vaccine
Clin Vaccine Immunol
PLoS One
Neurodegener Dis
Affiliations
Soon will be listed here.
Recent Articles
1.
Comparative functional potency of DNA vaccines encoding Plasmodium falciparum transmission blocking target antigens Pfs48/45 and Pfs25 administered alone or in combination by in vivo electroporation in rhesus macaques
Datta D, Bansal G, Grasperge B, Martin D, Philipp M, Gerloff D, et al.
Vaccine . 2017 Nov; 35(50):7049-7056. PMID: 29132995
Antibodies recognizing conformational epitopes in Pfs48/45, an antigen expressed on the surface of Plasmodium falciparum gametes and zygotes, have firmly established Pfs48/45 as a promising transmission blocking vaccine (TBV) candidate....
2.
Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation
Datta D, Bansal G, Gerloff D, Ellefsen B, Hannaman D, Kumar N
Vaccine . 2016 Dec; 35(2):264-272. PMID: 27912985
Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in the erythrocytic sexual stages and presentation to the immune system...
3.
A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation
Hannaman D, Dupuy L, Ellefsen B, Schmaljohn C
Vaccine . 2016 May; 34(31):3607-12. PMID: 27206386
Venezuelan equine encephalitis virus (VEEV), a mosquito-borne alphavirus, causes periodic epizootics in equines and is a recognized biological defense threat for humans. There are currently no FDA-licensed vaccines against VEEV....
4.
Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses
Bounds C, Kwilas S, Kuehne A, Brannan J, Bakken R, Dye J, et al.
PLoS One . 2015 Oct; 10(9):e0137786. PMID: 26422247
DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and Sudan virus (SUDV) produce fully human polyclonal antibodies (pAbs)...
5.
Evaluation of the Impact of Codon Optimization and N-Linked Glycosylation on Functional Immunogenicity of Pfs25 DNA Vaccines Delivered by In Vivo Electroporation in Preclinical Studies in Mice
Datta D, Bansal G, Kumar R, Ellefsen B, Hannaman D, Kumar N
Clin Vaccine Immunol . 2015 Jul; 22(9):1013-9. PMID: 26135972
Plasmodium falciparum sexual stage surface antigen Pfs25 is a well-established candidate for malaria transmission-blocking vaccine development. Immunization with DNA vaccines encoding Pfs25 has been shown to elicit potent antibody responses...
6.
Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons
Kumar R, Nyakundi R, Kariuki T, Ozwara H, Nyamongo O, Mlambo G, et al.
Vaccine . 2013 May; 31(31):3140-7. PMID: 23684840
Plasmodium falciparum Pfs25 antigen, expressed on the surface of zygotes and ookinetes, is one of the leading targets for the development of a malaria transmission-blocking vaccine (TBV). Our laboratory has...
7.
Two doses of bovine viral diarrhea virus DNA vaccine delivered by electroporation induce long-term protective immune responses
van Drunen Littel-van den Hurk S, Lawman Z, Snider M, Wilson D, van den Hurk J, Ellefsen B, et al.
Clin Vaccine Immunol . 2012 Dec; 20(2):166-73. PMID: 23220999
Bovine viral diarrhea virus (BVDV) is a pathogen of major importance in cattle, so there is a need for new effective vaccines. DNA vaccines induce balanced immune responses and are...
8.
Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses
Davtyan H, Ghochikyan A, Movsesyan N, Ellefsen B, Petrushina I, Cribbs D, et al.
Neurodegener Dis . 2012 Feb; 10(1-4):261-4. PMID: 22301697
Background: Induction of a humoral response against amyloid-β peptide may be beneficial for Alzheimer's disease (AD) patients and may alleviate the onset and progression of AD. DNA-based vaccination provides a...
9.
A DNA vaccine for venezuelan equine encephalitis virus delivered by intramuscular electroporation elicits high levels of neutralizing antibodies in multiple animal models and provides protective immunity to mice and nonhuman primates
Dupuy L, Richards M, Ellefsen B, Chau L, Luxembourg A, Hannaman D, et al.
Clin Vaccine Immunol . 2011 Apr; 18(5):707-16. PMID: 21450977
We evaluated the immunogenicity and protective efficacy of a DNA vaccine expressing codon-optimized envelope glycoprotein genes of Venezuelan equine encephalitis virus (VEEV) when delivered by intramuscular electroporation. Mice vaccinated with...
10.
Immunogenicity, safety, biodistribution and persistence of ADVAX, a prophylactic DNA vaccine for HIV-1, delivered by in vivo electroporation
Dolter K, Evans C, Ellefsen B, Song J, Boente-Carrera M, Vittorino R, et al.
Vaccine . 2010 Nov; 29(4):795-803. PMID: 21094270
ADVAX is a DNA-based candidate HIV vaccine that was safe but weakly immunogenic when delivered intramuscularly (IM) in humans. Studies were performed in animal models to determine whether an alternative...