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Balazs Jojart

Explore the profile of Balazs Jojart including associated specialties, affiliations and a list of published articles. Areas
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Articles 33
Citations 170
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Recent Articles
1.
Nemeth L, Martinek T, Jojart B
J Chem Inf Model . 2022 Oct; 62(20):4963-4969. PMID: 36190907
Cationic antimicrobial peptide PGLa gets into close contact with the anionic bacterial cell membrane, facilitating cross-membrane transport phenomena and membrane disruption depending on the concentration. The mechanisms of action are...
2.
Bhaumik K, Hetenyi A, Olajos G, Martins A, Spohn R, Nemeth L, et al.
Mol Syst Des Eng . 2022 Feb; 7(1):21-33. PMID: 35127141
The negative membrane potential of bacterial cells influences crucial cellular processes. Inspired by the molecular scaffold of the antimicrobial peptide PGLa, we have developed antimicrobial foldamers with a computer-guided design...
3.
Lopata A, Jojart B, Suranyi E, Takacs E, Bezur L, Leveles I, et al.
Biomolecules . 2019 Oct; 9(10). PMID: 31627475
EDTA is commonly used as an efficient chelator of metal ion enzyme cofactors. It is highly soluble, optically inactive and does not interfere with most chemicals used in standard buffers...
4.
Rozsa Z, Nemeth L, Jojart B, Nehez K, Viskolcz B, Szori M
J Phys Chem B . 2019 Aug; 123(37):7869-7884. PMID: 31452375
1,4-Dioxane is a cytotoxic B2-type human carcinogen, a serious water pollutant produced solely by industrial activity. The effect of 1,4-dioxane on phospholipid membrane models composed of dipalmitoyl-phosphatidylcholine (DPPC) and its...
5.
Jojart B, Orgovan Z, Marki A, Pandy-Szekeres G, Ferenczy G, Keseru G
J Biomol Struct Dyn . 2019 Jul; 38(9):2624-2632. PMID: 31258022
Metabotropic glutamate receptor 5 (mGluR5) is a class C G protein-coupled receptor (GPCR) with both an extracellular ligand binding site and an allosteric intrahelical chamber located similarly to the orthosteric...
6.
Hamid A, Salvatore J, Wang K, Murahari P, Guljas A, Ragyanszki A, et al.
Comput Biol Chem . 2019 May; 80:259-269. PMID: 31048244
In order to study the effects of peptide exposure to oxidative attack, we chose a model reaction in which the hydroxyl radical discretely abstracts a hydrogen atom from the α-carbon...
7.
Hantal G, Fabian B, Sega M, Jojart B, Jedlovszky P
Biochim Biophys Acta Biomembr . 2018 Dec; 1861(3):594-609. PMID: 30571949
Computer simulations of four lipid membranes of different compositions, namely neat DPPC and PSM, and equimolar DPPC-cholesterol and PSM-cholesterol mixtures, are performed in the presence and absence of the general...
8.
Kiss R, Zhu M, Jojart B, Czajlik A, Solti K, Forizs B, et al.
Biochim Biophys Acta Gen Subj . 2017 Aug; 1861(11 Pt A):2619-2629. PMID: 28844983
DJ-1 (PARK7) is a multifunctional protein linked to the onset and progression of a number of diseases, most of which are associated with high oxidative stress. The Cys106 of DJ-1...
9.
Lopata A, Leveles I, Bendes A, Viskolcz B, Vertessy B, Jojart B, et al.
J Biol Chem . 2016 Nov; 291(51):26320-26331. PMID: 27815500
dUTPases catalyze the hydrolysis of dUTP into dUMP and pyrophosphate to maintain the proper nucleotide pool for DNA metabolism. Recent evidence suggests that dUTPases may also represent a selective drug...
10.
Kiss R, Jojart B, Schmidt E, Kiss B, Keseru G
Mol Inform . 2016 Aug; 33(4):264-8. PMID: 27485772
We report the identification of novel histamine H4 receptor ligands by ensemble docking on homology model conformers derived from molecular dynamics simulations. Selected receptor models from the trajectories demonstrated superior...