Bakul S Bhatnagar
Overview
Explore the profile of Bakul S Bhatnagar including associated specialties, affiliations and a list of published articles.
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7
Citations
125
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Recent Articles
1.
Bhatnagar B, Sonje J, Shalaev E, Martin S, Teagarden D, Suryanarayanan R
Phys Chem Chem Phys
. 2020 Jan;
22(3):1583-1590.
PMID: 31894786
While water is the solvent of choice for the lyophilization of pharmaceuticals, tert-butyl alcohol (TBA) along with water can confer several advantages including increased solubility of hydrophobic drugs, decreased drying...
2.
Bhatnagar B, Martin S, Hodge T, Das T, Joseph L, Teagarden D, et al.
J Pharm Sci
. 2011 Apr;
100(8):3062-3075.
PMID: 21491456
The objectives of the current study were to investigate (i) the phase behavior of a PEGylated recombinant human growth hormone (PEG-rhGH, ∼60 kDa) during freeze-drying and (ii) its storage stability....
3.
Bhatnagar B, Martin S, Teagarden D, Shalaev E, Suryanarayanan R
J Pharm Sci
. 2010 Sep;
99(11):4510-24.
PMID: 20845450
Our objective was to characterize, by DSC and XRD, the equilibrium thermal behavior of frozen aqueous solutions containing polyethylene glycol (PEG) and sucrose. Aqueous solutions of (i) PEG (2.5-50% w/w),...
4.
Bhatnagar B, Martin S, Teagarden D, Shalaev E, Suryanarayanan R
J Pharm Sci
. 2010 Jan;
99(6):2609-19.
PMID: 20091827
Our objective was to characterize the nonequilibrium thermal behavior of frozen aqueous solutions containing PEG and sucrose. Aqueous solutions of (i) sucrose (10%, w/v) with different concentrations of PEG (1-20%,...
5.
Bhatnagar B, Bogner R, Pikal M
Pharm Dev Technol
. 2007 Oct;
12(5):505-23.
PMID: 17963151
Although proteins are often frozen during processing or freeze-dried after formulation to improve their stability, they can undergo degradation leading to losses in biological activity during the process. During freezing,...
6.
Bhatnagar B, Pikal M, Bogner R
J Pharm Sci
. 2007 May;
97(2):798-814.
PMID: 17506511
The objective of this study was to determine the individual contributions of ice formation, solute concentration, temperature, and time, to irreversible protein denaturation during freezing. A temperature-step approach was used...
7.
Bhatnagar B, Nehm S, Pikal M, Bogner R
J Pharm Sci
. 2005 Apr;
94(6):1382-8.
PMID: 15858849
Freeze-thawing is routinely used to study freezing-induced irreversible protein denaturation in the formulation characterization and development of lyophilized proteins. In most cases, the temperature profiles of the samples are not...