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Bahareh Honarparvar

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Citations 165
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Recent Articles
1.
Ntombela T, Seupersad A, Maseko S, Ibeji C, Tolufashe G, Maphumulo S, et al.
J Biomol Struct Dyn . 2021 Mar; 40(17):7645-7655. PMID: 33719919
cell wall is intricate and impermeable to many agents. A D, D-carboxypeptidase (DacB1) is one of the enzymes involved in the biosynthesis of cell wall peptidoglycan and catalyzes the terminal...
2.
Sanusi Z, Lawal M, Gupta P, Govender T, Baijnath S, Naicker T, et al.
J Biomol Struct Dyn . 2020 Oct; 40(4):1736-1747. PMID: 33073714
HIV-1 protease (HIV-1 PR) is an essential enzyme for the replication process of its virus, and therefore considered an important target for the development of drugs against the acquired immunodeficiency...
3.
Sanusi Z, Lawal M, Govender T, Baijnath S, Naicker T, Maguire G, et al.
Phys Chem Chem Phys . 2020 Jan; 22(4):2530-2539. PMID: 31942584
It is well known that understanding the catalytic mechanism of HIV-1 PR is the rationale on which its inhibitors were developed; therefore, a better understanding of the mechanism of natural...
4.
Sabe V, Tolufashe G, Ibeji C, Maseko S, Govender T, Maguire G, et al.
J Mol Model . 2019 Oct; 25(11):328. PMID: 31656981
Virtual screening is a useful in silico approach to identify potential leads against various targets. It is known that carbapenems (doripenem and faropenem) do not show any reasonable inhibitory activities...
5.
Sanusi Z, Lawal M, Govender T, Maguire G, Honarparvar B, Kruger H
J Phys Chem B . 2019 Jul; 123(30):6389-6400. PMID: 31283878
The Human Immunodeficiency Virus type 1 (HIV-1) protease is a crucial target for HIV/AIDS treatment, and understanding its catalytic mechanism is the basis on which HIV-1 enzyme inhibitors are developed....
6.
Ibeji C, Lawal M, Tolufashe G, Govender T, Naicker T, Maguire G, et al.
Chemphyschem . 2019 Apr; 20(9):1126-1134. PMID: 30969480
β-lactam antibiotics, which are used to treat infectious diseases, are currently the most widely used class of antibiotics. This study focused on the chemical reactivity of five- and six-membered ring...
7.
Tolufashe G, Sabe V, Ibeji C, Lawal M, Govender T, Maguire G, et al.
J Mol Graph Model . 2018 Dec; 87:204-210. PMID: 30554066
Tuberculosis (TB) is one of the world's deadliest diseases resulting from infection by the bacterium, Mycobacterium tuberculosis (M.tb). The L,D-transpeptidase enzymes catalyze the synthesis of 3 → 3 transpeptide linkages...
8.
Ibeji C, Tolufashe G, Ntombela T, Govender T, Maguire G, Lamichhane G, et al.
Tuberculosis (Edinb) . 2018 Dec; 113:222-230. PMID: 30514506
Mycobacterium tuberculosis is the causative agent of Tuberculosis. Formation of 3 → 3 crosslinks in the peptidoglycan layer of M. tuberculosis is catalyzed by l,d-transpeptidases. These enzymes can confer resistance...
9.
Tolufashe G, Sabe V, Ibeji C, Ntombela T, Govender T, Maguire G, et al.
Curr Med Chem . 2018 Dec; 27(19):3250-3267. PMID: 30501595
Peptidoglycan, the exoskeleton of bacterial cell and an essential barrier that protects the cell, is synthesized by a pathway where the final steps are catalysed by transpeptidases. Knowledge of the...
10.
Lawal M, Sanusi Z, Govender T, Maguire G, Honarparvar B, Kruger H
Curr Med Chem . 2018 Nov; 27(15):2514-2549. PMID: 30421668
Current investigations on the Human Immunodeficiency Virus Protease (HIV-1 PR) as a druggable target towards the treatment of AIDS require an update to facilitate further development of promising inhibitors with...