B W Matthews
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Explore the profile of B W Matthews including associated specialties, affiliations and a list of published articles.
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238
Citations
12162
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Recent Articles
1.
Eijsink V, Matthews B, Vriend G
Protein Sci
. 2011 Jun;
20(8):1346-55.
PMID: 21648000
Thermolysin and other secreted broad-specificity proteases, such as subtilisin or alpha-lytic protease, are produced as pre-pro-proteins that stay at least partially unfolded while in the cytosol. After secretion, the pro-proteases...
2.
Juers D, Heightman T, Vasella A, McCarter J, Mackenzie L, Withers S, et al.
Biochemistry
. 2001 Dec;
40(49):14781-94.
PMID: 11732897
The structures of a series of complexes designed to mimic intermediates along the reaction coordinate for beta-galactosidase are presented. These complexes clarify and enhance previous proposals regarding the catalytic mechanism....
3.
Weaver L, Kwon K, Beckett D, Matthews B
Protein Sci
. 2001 Nov;
10(12):2618-22.
PMID: 11714930
A model is suggested for the complex between the biotin repressor of Escherichia coli, BirA, and BCCP, the biotin carboxyl carrier protein to which BirA transfers biotin. The model is...
4.
Hausrath A, Capaldi R, Matthews B
J Biol Chem
. 2001 Oct;
276(50):47227-32.
PMID: 11585832
F(1) is the water-soluble portion of the ubiquitous F(1)F(0) ATP synthase. Its structure includes three alpha- and three beta-subunits, arranged as a hexameric disc, plus a gamma-subunit that penetrates the...
5.
Juers D, Matthews B
J Mol Biol
. 2001 Aug;
311(4):851-62.
PMID: 11518535
Flash-freezing, which has become routine in macromolecular X-ray crystallography, causes the crystal to contract substantially. In the case of Escherichia coli beta-galactosidase the changes are reversible and are shown to...
6.
Breyer W, Matthews B
Protein Sci
. 2001 Aug;
10(9):1699-711.
PMID: 11514661
The structures of a number of processive enzymes have been determined recently. These proteins remain attached to their polymeric substrates and may perform thousands of rounds of catalysis before dissociating....
7.
Sagermann M, Stevens T, Matthews B
Proc Natl Acad Sci U S A
. 2001 Jun;
98(13):7134-9.
PMID: 11416198
In contrast to the F-type ATPases, which use a proton gradient to generate ATP, the V-type enzymes use ATP to actively transport protons into organelles and extracellular compartments. We describe...
8.
Weaver L, Kwon K, Beckett D, Matthews B
Proc Natl Acad Sci U S A
. 2001 May;
98(11):6045-50.
PMID: 11353844
The Escherichia coli biotin repressor binds to the biotin operator to repress transcription of the biotin biosynthetic operon. In this work, a structure determined by x-ray crystallography of a complex...
9.
Xu J, Baase W, Quillin M, Baldwin E, Matthews B
Protein Sci
. 2001 Apr;
10(5):1067-78.
PMID: 11316887
To investigate the structural and thermodynamic basis of the binding of solvent at internal sites within proteins a number of mutations were constructed in T4 lysozyme. Some of these were...
10.
Su A, Lorber D, Weston G, Baase W, Matthews B, Shoichet B
Proteins
. 2000 Dec;
42(2):279-93.
PMID: 11119652
Molecular docking programs screen chemical databases for novel ligands that fit protein binding sites. When one compound fits the site well, close analogs typically do the same. Therefore, many of...