B Spohn
Overview
Explore the profile of B Spohn including associated specialties, affiliations and a list of published articles.
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17
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1313
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Recent Articles
1.
Gieseler F, Boege F, Biersack H, Spohn B, Clark M, Wilms K
Leuk Lymphoma
. 2016 Jul;
5(4):273-9.
PMID: 27467850
We have studied the effect of dimethyl-sulfoxide(DMSO)-induced granulocytic differentiation on the sensitivity of HL-60 cells to various cytotoxic topoisomerase II inhibitors: (i) undifferentiated HL-60 cells are highly sensitive to etoposide,...
2.
Zhou B, Liao Y, Xia W, Zou Y, Spohn B, Hung M
Nat Cell Biol
. 2001 Nov;
3(11):973-82.
PMID: 11715018
HER-2/neu amplification or overexpression can make cancer cells resistant to apoptosis and promotes their growth. p53 is crucial in regulating cell growth and apoptosis, and is often mutated or deleted...
3.
Wen Y, Yan D, Wang B, Spohn B, Ding Y, Shao R, et al.
Cancer Res
. 2001 Oct;
61(19):7142-7.
PMID: 11585747
p202, an IFN-inducible protein, interacts with certain transcriptional activators leading to transcriptional repression. p202 expression has been associated with inhibition of cancer cell growth in vitro and in vivo. To...
4.
Zhou B, Liao Y, Xia W, Spohn B, Lee M, Hung M
Nat Cell Biol
. 2001 Mar;
3(3):245-52.
PMID: 11231573
Amplification or overexpression of HER-2/neu in cancer cells confers resistance to apoptosis and promotes cell growth. The cellular localization of p21Cip1/WAF1 has been proposed to be critical either in promoting...
5.
Wen Y, Hu M, Makino K, Spohn B, Bartholomeusz G, Yan D, et al.
Cancer Res
. 2001 Jan;
60(24):6841-5.
PMID: 11156376
HER-2/neu has been implicated in the activation of androgen receptor (AR) and in inducing hormone-independent prostate cancer growth. Here we report that HER-2/neu activates Akt (protein kinase B) to promote...
6.
Lin S, Xia W, Wang J, Kwong K, Spohn B, Wen Y, et al.
Proc Natl Acad Sci U S A
. 2000 Apr;
97(8):4262-6.
PMID: 10759547
Beta-catenin can function as an oncogene when it is translocated to the nucleus, binds to T cell factor or lymphoid enhancer factor family members, and transactivates its target genes. In...
7.
Wen Y, Yan D, Spohn B, Deng J, Lin S, Hung M
Cancer Res
. 2000 Jan;
60(1):42-6.
PMID: 10646849
p202, an IFN-inducible protein, interacts with several important regulatory proteins, leading to growth arrest or differentiation. In this report, we demonstrate that, in addition to inhibiting in vitro cell growth,...
8.
Shao R, Hu M, Zhou B, Lin S, Chiao P, von Lindern R, et al.
J Biol Chem
. 1999 Jul;
274(31):21495-8.
PMID: 10419449
The adenovirus E1A protein has been implicated in increasing cellular susceptibility to apoptosis induced by tumor necrosis factor (TNF); however, its mechanism of action is still unknown. Since activation of...
9.
Yan D, Wen Y, Spohn B, Choubey D, Gutterman J, Hung M
Oncogene
. 1999 Feb;
18(3):807-11.
PMID: 9989832
Interferons (IFNs) can exert cytostatic and immunomodulatory effects on carcinoma cells. In particular, growth inhibition of human prostate carcinoma by IFNs has been demonstrated both in vitro and in vivo....
10.
Crowley P, Provencher L, Sloane S, Dugatkin L, Spohn B, Rogers L, et al.
Biosystems
. 1996 Jan;
37(1-2):49-66.
PMID: 8924639
To evaluate the role of individual recognition in the evolution of cooperation, we formulated and analyzed genetic algorithm model (EvCo) for playing the Iterated Prisoner's Dilemma (IPD) game. Strategies compete...