B S Meldrum
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Explore the profile of B S Meldrum including associated specialties, affiliations and a list of published articles.
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316
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3588
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Recent Articles
1.
Meldrum B
Epilepsia
. 2012 Oct;
36 Suppl 1:S30-5.
PMID: 23057108
Some evidence indicates that in some types of focal epilepsy the enhanced excitability is due in part to impaired gamma-aminobutyric acid (GABA)ergic inhibitory feedback. One form that this can take...
2.
Meldrum B, Kerwin R
J Psychopharmacol
. 2011 Dec;
1(4):217-21.
PMID: 22159133
No abstract available.
3.
Chapman A, Faingold C, Hart G, Bowker H, Meldrum B
Neurochem Int
. 2010 May;
8(2):273-9.
PMID: 20493057
Regional brain amino acid levels have been determined by HPLC, following microwave fixation, in seizure susceptible (University of Arizona, Audiogenic seizure-susceptible, AGS) and non-seizure susceptible Sprague-Dawley rats. Glutamine content is...
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Chapman A, Talebi A, Yip P, Meldrum B
Eur J Pharmacol
. 2001 Jul;
424(2):107-13.
PMID: 11476756
The metabotropic Group III agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid (ACPT-1), selective for the mGlu(4alpha) receptor, suppresses sound-induced seizures in DBA/2 mice following its intracerebroventricular (i.c.v.) administration (ED(50) 5.6 [2.9-10.7], nmol i.c.v., 15...
7.
Moldrich R, Jeffrey M, Talebi A, Beart P, Chapman A, Meldrum B
Neuropharmacology
. 2001 Jul;
41(1):8-18.
PMID: 11445181
The selective group II metabotropic glutamate receptor (mGlu(2/3)) agonists (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268) and (-)-2-thia-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY389795) have been evaluated as anti-epileptic drugs in dilute brown agouti (DBA/2) mice, lethargic (lh/lh) mice, genetically...
8.
Yip P, Meldrum B, Rattray M
J Neurochem
. 2001 Jul;
78(1):13-23.
PMID: 11432969
The selective group-III metabotropic glutamate receptor agonist, L-serine-O-phosphate (L-SOP), when injected bilaterally into the inferior colliculus of the sound sensitive genetically epilepsy-prone (GEP) rats produces a short proconvulsant excitation followed...
9.
Cash D, Beech J, Rayne R, Bath P, Meldrum B, Williams S
Brain Res
. 2001 Jun;
905(1-2):91-103.
PMID: 11423083
Using serial magnetic resonance imaging we have evaluated the effectiveness of aminoguanidine (AG) as a neuroprotective agent in a rat model of transient middle cerebral artery occlusion (MCAO). Because aminoguanidine's...
10.
Moldrich R, Beart P, Jane D, Chapman A, Meldrum B
Neuropharmacology
. 2001 Apr;
40(5):732-5.
PMID: 11311902
The 3,4-dicarboxyphenylglycines (3,4-DCPG) inhibit sound-induced seizures in DBA/2 mice with the racemate being notably more potent than either isomer (ED(50) (nmol, i.c.v.)): (RS)-3,4-DCPG (0.004; 86 mg/kg, i.p.)>>the mGlu(8) agonist (S)-3,4-DCPG...