B M Bradt
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Explore the profile of B M Bradt including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
243
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Recent Articles
1.
Mirick G, Bradt B, Denardo S, Denardo G
Q J Nucl Med Mol Imaging
. 2005 Jan;
48(4):251-7.
PMID: 15640788
The United States Food and Drug Administration (FDA) has approved unconjugated monoclonal antibodies (MAbs) for immunotherapy (IT) of B-cell lymphoma, breast cancer and acute myeloid leukemia. More recently, approval has...
2.
Yu J, Bradt B, Cooper N
Immunogenetics
. 2000 Sep;
51(10):779-87.
PMID: 10970092
The sixth complement component (C6) is an essential component of the biologically active C5b-9 membrane attack complex of the complement system. The multimolecular C5b-9 complex is an important mediator of...
3.
Cooper N, Bradt B, OBarr S, Yu J
Immunol Res
. 2000 Jun;
21(2-3):159-65.
PMID: 10852113
We hypothesize that amyloid (Abeta) peptide-containing neuritic plaques in the brains of patients with Alzheimer's disease represent chronic inflammatory foci mediated by the actions of the complement system and proinflammatory...
4.
Bradt B, KOLB W, Cooper N
J Exp Med
. 1998 Aug;
188(3):431-8.
PMID: 9687521
Large numbers of neuritic plaques (NP), largely composed of a fibrillar insoluble form of the beta-amyloid peptide (Abeta), are found in the hippocampus and neocortex of Alzheimer's disease (AD) patients...
5.
Ogata R, Low P, Bradt B, Cooper N
J Immunol
. 1994 Jun;
152(12):5890-5.
PMID: 8207214
An early step in the initiation of the classical C pathway is the proteolytic activation of component C4 by subcomponent C1-s. We have examined the substrate specificity of murine C1-s...
6.
Murine C4b-binding protein. Mapping of the ligand binding site and the N-terminus of the pre-protein
Ogata R, Mathias P, Bradt B, Cooper N
J Immunol
. 1993 Mar;
150(6):2273-80.
PMID: 8450212
We have constructed cell surface-bound forms of murine C4b-binding protein (mC4BP) that allowed us to monitor the binding of mC4BP to C4b with relatively simple erythrocyte rosette assays. We used...
7.
Cooper N, Bradt B, Rhim J, Nemerow G
J Invest Dermatol
. 1990 Jun;
94(6 Suppl):112S-117S.
PMID: 2161885
CR2, a membrane glycoprotein, is one of a number of cell-surface proteins which bind activation and processing fragments of the complement system. CR2, which is found on normal B lymphocytes,...
8.
Ogata R, Cooper N, Bradt B, Mathias P, Picchi M
Proc Natl Acad Sci U S A
. 1989 Jul;
86(14):5575-9.
PMID: 2748603
Murine sex-limited protein (Slp) is an isotype of murine complement component C4 that shares 95% sequence identity with C4 as well as the intramolecular thioester necessary for C4 function but...
9.
Picchi M, Bradt B, Cooper N, Ogata R
Complement Inflamm
. 1989 Jan;
6(6):442-52.
PMID: 2513164
Previously cloned and sequenced full-length cDNAs for murine C4 and the closely related sex-limited protein (Slp) have been placed into an eucaryotic expression vector. Transfer of these DNA constructs transiently...
10.
Mold C, Bradt B, Nemerow G, Cooper N
J Exp Med
. 1988 Sep;
168(3):949-69.
PMID: 2844953
Serum incubated with purified EBV was found to contain C3 cleavage fragments characteristic of C3c. Since the cofactors necessary for such cleavage of C3b by factor I are not normally...