B L Hempstead
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Explore the profile of B L Hempstead including associated specialties, affiliations and a list of published articles.
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43
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2843
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Recent Articles
1.
Hempstead B
Handb Exp Pharmacol
. 2014 Mar;
220:17-32.
PMID: 24668468
Like most growth factors, neurotrophins are initially synthesized as precursors that are cleaved to release C-terminal mature forms. The well-characterized mature neurotrophins bind to Trk receptors to initiate survival and...
2.
Tessarollo L, Hempstead B
Trends Cardiovasc Med
. 2011 Jan;
8(1):34-40.
PMID: 21235910
The development of a functional heart depends on the coordinated growth, differentiation, migration, and apoptosis of cell populations of diverse embryological origins. These processes are regulated in part by soluble...
3.
Casey B, Glatt C, Tottenham N, Soliman F, Bath K, Amso D, et al.
Neuroscience
. 2009 Apr;
164(1):108-20.
PMID: 19358879
There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These...
4.
Harrington A, Leiner B, Blechschmitt C, Arevalo J, Lee R, Morl K, et al.
Proc Natl Acad Sci U S A
. 2004 Mar;
101(16):6226-30.
PMID: 15026568
The unprocessed precursor of the neurotrophin nerve growth factor (NGF), proNGF, has been suggested to be a death-inducing ligand for the neurotrophin receptor p75. Whether proNGF is a true pathophysiological...
5.
Teng K, Hempstead B
Cell Mol Life Sci
. 2004 Jan;
61(1):35-48.
PMID: 14704852
The neurotrophins, a class of four related growth factors, utilize a dual receptor system consisting of Trk receptor tyrosine kinases and the structurally unrelated p75(NTR) to modulate diverse and sometimes...
6.
Lee R, Kermani P, Teng K, Hempstead B
Science
. 2001 Dec;
294(5548):1945-8.
PMID: 11729324
Neurotrophins are growth factors that promote cell survival, differentiation, and cell death. They are synthesized as proforms that can be cleaved intracellularly to release mature, secreted ligands. Although proneurotrophins have...
7.
Esposito D, Patel P, Stephens R, Perez P, Chao M, Kaplan D, et al.
J Biol Chem
. 2001 Jul;
276(35):32687-95.
PMID: 11435417
Ligand-induced receptor oligomerization is an established mechanism for receptor-tyrosine kinase activation. However, numerous receptor-tyrosine kinases are expressed in multicomponent complexes with other receptors that may signal independently or alter the...
8.
Das I, Sparrow J, Lin M, Shih E, Mikawa T, Hempstead B
J Neurosci
. 2001 Feb;
20(8):2887-95.
PMID: 10751441
Although neurotrophin actions in the survival of specific retinal cell types have been identified, the biological functions for neurotrophin-3 (NT-3) in early retinal development remain unclear. Having localized NT-3 and...
9.
Donovan M, Lin M, Wiegn P, Ringstedt T, Kraemer R, Hahn R, et al.
Development
. 2000 Oct;
127(21):4531-40.
PMID: 11023857
Brain derived neurotrophic factor, BDNF, is a neurotrophin best characterized for its survival and differentiative effects on neurons expressing the trk B receptor tyrosine kinase. Although many of these neurons...
10.
Lin M, Das I, Schwartz G, Tsoulfas P, Mikawa T, Hempstead B
Dev Biol
. 2000 Oct;
226(2):180-91.
PMID: 11023679
Neurotrophin-3 (NT-3) is a member of the neurotrophin family of growth factors, best characterized by its survival- and differentiation-inducing effects on developing neurons bearing the trk C receptor tyrosine kinase....