B K Shoichet
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Explore the profile of B K Shoichet including associated specialties, affiliations and a list of published articles.
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24
Citations
906
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Recent Articles
1.
Irwin J, Pottel J, Zou L, Wen H, Zuk S, Zhang X, et al.
Clin Pharmacol Ther
. 2016 Aug;
101(3):320-323.
PMID: 27557422
Excipients are ubiquitous in drug formulation, ensuring that active ingredient drugs are properly released on dosing, retain their properties over time, and are palatable, among other roles. Despite their crucial...
2.
Powers R, Caselli E, Focia P, Prati F, Shoichet B
Biochemistry
. 2001 Aug;
40(31):9207-14.
PMID: 11478888
Third-generation cephalosporins are widely used beta-lactam antibiotics that resist hydrolysis by beta-lactamases. Recently, mutant beta-lactamases that rapidly inactivate these drugs have emerged. To investigate why third-generation cephalosporins are relatively stable...
3.
Trehan I, Beadle B, Shoichet B
Biochemistry
. 2001 Jul;
40(27):7992-9.
PMID: 11434768
Beta-lactamases hydrolyze beta-lactam antibiotics, including penicillins and cephalosporins; these enzymes are the most widespread resistance mechanism to these drugs and pose a growing threat to public health. beta-Lactams that contain...
4.
Tondi D, Powers R, Caselli E, Negri M, Blazquez J, Costi M, et al.
Chem Biol
. 2001 Jun;
8(6):593-611.
PMID: 11410378
Background: Group I beta-lactamases are a major cause of antibiotic resistance to beta-lactams such as penicillins and cephalosporins. These enzymes are only modestly affected by classic beta-lactam-based inhibitors, such as...
5.
Beadle B, Nicholas R, Shoichet B
Protein Sci
. 2001 May;
10(6):1254-9.
PMID: 11369864
Penicillin-binding proteins (PBPs) catalyze the final stages of bacterial cell wall biosynthesis. PBPs form stable covalent complexes with beta-lactam antibiotics, leading to PBP inactivation and ultimately cell death. To understand...
6.
Caselli E, Powers R, Blasczcak L, Wu C, Prati F, Shoichet B
Chem Biol
. 2001 Feb;
8(1):17-31.
PMID: 11182316
Background: Penicillins and cephalosporins are among the most widely used and successful antibiotics. The emergence of resistance to these beta-lactams, most often through bacterial expression of beta-lactamases, threatens public health....
7.
Su A, Lorber D, Weston G, Baase W, Matthews B, Shoichet B
Proteins
. 2000 Dec;
42(2):279-93.
PMID: 11119652
Molecular docking programs screen chemical databases for novel ligands that fit protein binding sites. When one compound fits the site well, close analogs typically do the same. Therefore, many of...
8.
Powers R, Blazquez J, Weston G, Morosini M, Baquero F, Shoichet B
Protein Sci
. 1999 Dec;
8(11):2330-7.
PMID: 10595535
Beta-lactamases are the major resistance mechanism to beta-lactam antibiotics and pose a growing threat to public health. Recently, bacteria have become resistant to beta-lactamase inhibitors, making this problem pressing. In...
9.
Beadle B, McGovern S, Patera A, Shoichet B
Protein Sci
. 1999 Sep;
8(9):1816-24.
PMID: 10493583
Despite decades of intense study, the complementarity of beta-lactams for beta-lactamases and penicillin binding proteins is poorly understood. For most of these enzymes, beta-lactam binding involves rapid formation of a...
10.
Shoichet B, Leach A, Kuntz I
Proteins
. 1999 May;
34(1):4-16.
PMID: 10336382
Solvation plays an important role in ligand-protein association and has a strong impact on comparisons of binding energies for dissimilar molecules. When databases of such molecules are screened for complementarity...