B de Crombrugghe
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Explore the profile of B de Crombrugghe including associated specialties, affiliations and a list of published articles.
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192
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8453
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Recent Articles
1.
Jing Y, Zhou X, Han X, Jing J, von der Mark K, Wang J, et al.
J Dent Res
. 2015 Sep;
94(12):1668-75.
PMID: 26341973
For decades, it has been widely accepted that hypertrophic chondrocytes undergo apoptosis prior to endochondral bone formation. However, very recent studies in long bone suggest that chondrocytes can directly transform...
2.
Kim T, Bae C, Lee J, Kim J, Yang X, de Crombrugghe B, et al.
J Dent Res
. 2015 Jan;
94(3):430-8.
PMID: 25568170
Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc...
3.
Wang J, Sonnylal S, Arnett F, de Crombrugghe B, Zhou X
Int J Immunopathol Pharmacol
. 2011 Oct;
24(3):595-601.
PMID: 21978691
Transgenic mice that over-express connective tissue growth factor (CTGF) in fibroblasts under the control of an enhancer/promoter element of the Col1a2 gene (Col1a2-CTGF) recapitulate multiorgan fibrosis similar to fibrosis observed...
4.
Schaefer J, Millham M, de Crombrugghe B, Buckbinder L
Osteoarthritis Cartilage
. 2003 Apr;
11(4):233-41.
PMID: 12681949
Objective: The Sox9 transcription factor has emerged as an important determinant of chondrocyte differentiation, including the regulation of type II collagen (Col2) and aggrecan gene expression. We sought to identify...
5.
Smits P, Li P, Mandel J, Zhang Z, Deng J, Behringer R, et al.
Dev Cell
. 2001 Nov;
1(2):277-90.
PMID: 11702786
L-Sox5 and Sox6 are highly identical Sry-related transcription factors coexpressed in cartilage. Whereas Sox5 and Sox6 single null mice are born with mild skeletal abnormalities, Sox5; Sox6 double null fetuses...
6.
de Crombrugghe B, Lefebvre V, Nakashima K
Curr Opin Cell Biol
. 2001 Nov;
13(6):721-7.
PMID: 11698188
Three transcription factors of the Sox family have essential roles in different steps of the chondrocyte differentiation pathway. Because the transcription factor Cbfa1, which is needed for osteoblast differentiation, also...
7.
Lefebvre V, Behringer R, de Crombrugghe B
Osteoarthritis Cartilage
. 2001 Oct;
9 Suppl A:S69-75.
PMID: 11680692
Objective: This work was carried out to identify transcription factors controlling the differentiation of mesenchymal cells into chondrocytes. Design: We delineated a cartilage-specific enhancer in the collagen type 2 gene...
8.
Coustry F, Hu Q, de Crombrugghe B, Maity S
J Biol Chem
. 2001 Aug;
276(44):40621-30.
PMID: 11514576
To understand the role of CCAAT-binding factor (CBF) in transcription in the context of chromatin-assembled DNA, we used regularly spaced nucleosomal DNA using topoisomerase IIalpha (topo IIalpha) and alpha2(1) collagen...
9.
Bi W, Huang W, Whitworth D, Deng J, Zhang Z, Behringer R, et al.
Proc Natl Acad Sci U S A
. 2001 May;
98(12):6698-703.
PMID: 11371614
In humans, SOX9 heterozygous mutations cause the severe skeletal dysmorphology syndrome campomelic dysplasia. Except for clinical descriptions, little is known about the pathogenesis of this disease. We have generated heterozygous...
10.
Antoniv T, De Val S, Wells D, Denton C, Rabe C, de Crombrugghe B, et al.
J Biol Chem
. 2001 Mar;
276(24):21754-64.
PMID: 11279244
We have examined the chromatin structure around and upstream of the transcriptional start site of the human alpha2(I) collagen (COL1A2) gene. Four strong DNase I-hypersensitive sites (HS2-5) were only detected...