B Darpo
Overview
Explore the profile of B Darpo including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
260
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Recent Articles
1.
Darpo B, Benson C, Dota C, Ferber G, Garnett C, Green C, et al.
Clin Pharmacol Ther
. 2015 Feb;
97(4):326-35.
PMID: 25670536
The QT effects of five "QT-positive" and one negative drug were tested to evaluate whether exposure-response analysis can detect QT effects in a small study with healthy subjects. Each drug...
2.
Fossa A, Langdon G, Couderc J, Zhou M, Darpo B, Wilson F, et al.
Clin Pharmacol Ther
. 2011 Aug;
90(3):449-54.
PMID: 21814193
QT correction factors (QTc) can cause errors in the interpretation of drug effects on cardiac repolarization because they do not adequately differentiate changes when heart rate or autonomic state deviates...
3.
Fosser C, Duczynski G, Agin M, Wicker P, Darpo B
Clin Pharmacol Ther
. 2009 Apr;
86(5):503-6.
PMID: 19339965
We analyzed five crossover, thorough QT (TQT) studies to compare automated, manual, and computer-assisted (CA) measurement methods. All the methods detected moxifloxacin-induced, baseline-adjusted, placebo-subtracted mean changes in Fridericia-corrected QT interval...
4.
Bass A, Darpo B, Breidenbach A, Bruse K, Feldman H, Garnes D, et al.
Br J Pharmacol
. 2008 Jul;
154(7):1491-501.
PMID: 18663380
Knowledge of the cardiac safety of emerging new drugs is an important aspect of assuring the expeditious advancement of the best candidates targeted at unmet medical needs while also assuring...
5.
Bass A, Darpo B, Valentin J, Sager P, Thomas K
Br J Pharmacol
. 2008 Jun;
154(7):1550-3.
PMID: 18574462
Drug-induced torsades de pointes (TdP) remains a significant public health concern that has challenged scientists who have the responsibility of advancing new medicines through development to the patient, while assuring...
6.
7.
Houltz B, Darpo B, Swedberg K, Blomstrom P, Crijns H, Jensen S, et al.
Europace
. 2001 Feb;
2(1):20-31.
PMID: 11225593
Aims: Drug-induced increase in QT dispersion has been associated with increased risk of ventricular proarrhythmia. The aim of the present study was to compare QT dispersion during atrial fibrillation and...
8.
Nanthakumar K, Bergfeldt L, Darpo B
Europace
. 2001 Feb;
1(1):55-62.
PMID: 11220543
Aims: Measurement of the refractory properties of asymptomatic overt accessory pathways is performed to assess the risk for significant arrhythmias. We hypothesized that a transoesophageal atrial stimulation (TAS) protocol would...
9.
Frick M, Darpo B, Ostergren J, Rosenqvist M
Eur Heart J
. 2000 Aug;
21(14):1177-85.
PMID: 10924301
Aims: To determine whether magnesium given orally decreases the recurrence rate of atrial fibrillation after elective direct current cardioversion of persistent atrial fibrillation. Methods And Results: Consecutive outpatients were randomized...
10.
Houltz B, Darpo B, Swedberg K, Blomstrom P, Brachmann J, Crijns H, et al.
Cardiovasc Drugs Ther
. 1999 Oct;
13(4):329-38.
PMID: 10516869
Purpose: To assess the efficacy of the Ikr-blocker almokalant attempting to convert chronic atrial tachyarrhythmias, and to find predictors of conversion, to sinus rhythm. Methods: The electrophysiological effects of a...