B D Gomperts
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Explore the profile of B D Gomperts including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Pinxteren J, Gomperts B, Rogers D, Phillips S, Tatham P, Thomas G
Biochem J
. 2001 May;
356(Pt 1):287-96.
PMID: 11336662
Mast cells permeabilized by streptolysin O undergo exocytosis when stimulated with Ca(2+) and guanosine 5'-[gamma-thio]triphosphate but become progressively refractory to this stimulus if it is delayed. This run-down of responsiveness...
2.
Pinxteren J, OSullivan A, Larbi K, Tatham P, Gomperts B
Biochimie
. 2000 Jun;
82(4):385-93.
PMID: 10865126
Calcium, initially considered as the universal link between receptor stimulation and the onset of exocytosis in secretory cells, is now recognised as only one of a number of intracellular activators....
3.
Pinxteren J, OSullivan A, Tatham P, Gomperts B
EMBO J
. 1998 Nov;
17(21):6210-8.
PMID: 9799230
We applied G protein-derived beta gamma-subunits to permeabilized mast cells to test their ability to regulate exocytotic secretion. Mast cells permeabilized with streptolysin-O leak soluble (cytosol) proteins over a period...
4.
Induction of exocytosis from permeabilized mast cells by the guanosine triphosphatases Rac and Cdc42
Brown A, OSullivan A, Gomperts B
Mol Biol Cell
. 1998 May;
9(5):1053-63.
PMID: 9571239
We applied recombinant forms of the Rho-related small guanosine triphosphatases (GTPases) Rac2 and Cdc42/G25K to permeabilized mast cells to test their ability to regulate exocytotic secretion. Mast cells permeabilized with...
5.
Larbi K, Gomperts B
Cell Calcium
. 1997 Mar;
21(3):213-9.
PMID: 9105730
Inhibition by Mg2+ ions of exocytotic secretion from permeabilised eosinophils, stimulated by Ca2+ and GTP gamma S, and in the presence and absence of ATP, has been examined. While Mg2+...
6.
Newman T, Tian M, Gomperts B
Eur J Cell Biol
. 1996 Jul;
70(3):209-20.
PMID: 8832205
We have used ultrastructural techniques to investigate secretion in permeabilized eosinophils. As each exocytotic event is rapid we have used tannic acid incubation to trap the maximum number of fusion...
7.
OSullivan A, Brown A, Freeman H, Gomperts B
Mol Biol Cell
. 1996 Mar;
7(3):397-408.
PMID: 8868468
Mast cells permeabilized by treatment with streptolysin-O in the presence of Ca2+ and GTP-gamma-S can secrete almost 100% of their contained N-acetyl-beta-D-glucosaminidase. If these stimuli are provided to the permeabilized...
8.
Larbi K, Gomperts B
Biosci Rep
. 1996 Feb;
16(1):11-21.
PMID: 8861536
Streptolysin-O is widely used in cell biological investigations in order to make large (>12 nm) pores in the plasma membrane and so to render the cytosol directly accessible to experimental...
9.
Lacy P, Thompson N, Tian M, Solari R, Hide I, Newman T, et al.
J Cell Sci
. 1995 Nov;
108 ( Pt 11):3547-56.
PMID: 8586666
We set out to identify potential key regulators of exocytotic fusion in the eosinophil, in the knowledge that granule exocytosis can be stimulated in these cells by intracellular application of...
10.
Martin M, OSullivan A, Gomperts B
Br J Pharmacol
. 1995 Jul;
115(6):1080-6.
PMID: 7582506
1. The anti-allergic compound, cromoglycate, is reported to possess affinity for, and to suppress the autophosphorylation of a 72kDa protein having the sequence of nucleoside diphosphate kinase (NDPK). 2. We...