B Arunachalam
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Explore the profile of B Arunachalam including associated specialties, affiliations and a list of published articles.
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12
Citations
384
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Recent Articles
1.
Maric M, Arunachalam B, Phan U, Dong C, GARRETT W, Cannon K, et al.
Science
. 2001 Nov;
294(5545):1361-5.
PMID: 11701933
Processing of proteins for major histocompatibility complex (MHC) class II-restricted presentation to CD4-positive T lymphocytes occurs after they are internalized by antigen-presenting cells (APCs). Antigenic proteins frequently contain disulfide bonds,...
2.
Phan U, Arunachalam B, Cresswell P
J Biol Chem
. 2000 Jun;
275(34):25907-14.
PMID: 10852914
We recently identified a gamma-interferon-inducible lysosomal thiol reductase (GILT), constitutively expressed in antigen-presenting cells, that catalyzes disulfide bond reduction both in vitro and in vivo and is optimally active at...
3.
Arunachalam B, Phan U, Geuze H, Cresswell P
Proc Natl Acad Sci U S A
. 2000 Jan;
97(2):745-50.
PMID: 10639150
Proteins internalized into the endocytic pathway are usually degraded. Efficient proteolysis requires denaturation, induced by acidic conditions within lysosomes, and reduction of inter- and intrachain disulfide bonds. Cytosolic reduction is...
4.
Cresswell P, Arunachalam B, Bangia N, Dick T, Diedrich G, Hughes E, et al.
Immunol Res
. 1999 Sep;
19(2-3):191-200.
PMID: 10493173
Major histocompatibility complex (MHC) class I molecules are assembled in the endoplasmic reticulum (ER) as a trimer of the class I heavy chain, beta2 microglobulin (beta2m), and a short peptide....
5.
Coady M, Mandapati D, Arunachalam B, Jensen K, Maher S, Bothwell A, et al.
Transplantation
. 1999 Jun;
67(11):1461-7.
PMID: 10385086
Background: Polymorphic class I and II major histo-: compatibility complex (MHC) genes are not transcribed in trophoblasts although many immune system cells express these genes constitutively. To study the molecular...
6.
Arunachalam B, Pan M, Cresswell P
J Immunol
. 1998 Jun;
160(12):5797-806.
PMID: 9637490
The generation of invariant chain-free MHC class II molecules and their association with endocytically generated peptides are thought to occur in specialized lysosome-like compartments called MIICs (MHC class II compartments)....
7.
Arunachalam B, Cresswell P
J Biol Chem
. 1995 Feb;
270(6):2784-90.
PMID: 7852350
Molecular chaperones are believed to retain misfolded and incompletely assembled oligomeric proteins in the endoplasmic reticulum (ER). Here, we have further analyzed the association of one such chaperone, calnexin, with...
8.
Arunachalam B, Lamb C, Cresswell P
Int Immunol
. 1994 Mar;
6(3):439-51.
PMID: 8186195
Major histocompatibility complex (MHC) class II molecules are heterodimers of alpha and beta subunits that associate intracellularly with the invariant chain. Human invariant chain exists in four forms, p33, p35,...
9.
Arunachalam B, Ghosh S, Talwar G, Raghupathy R
Hybridoma
. 1992 Apr;
11(2):165-79.
PMID: 1376715
Protective human monoclonal antibodies (HuMAbs) are superior to hyperimmune sera and murine monoclonal antibodies as far as human immunotherapy is concerned. In this report, we describe the successful generation of...
10.
Arunachalam B, Talwar G, Raghupathy R
J Immunol Methods
. 1990 Dec;
135(1-2):181-9.
PMID: 2273257
This paper describes the adaptation of a cellular enzyme-linked immunosorbent assay (CELISA) for the detection of antibodies to cell-surface antigens. This CELISA has the advantages of convenience and rapidity and...