B A Witthuhn
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Explore the profile of B A Witthuhn including associated specialties, affiliations and a list of published articles.
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31
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2792
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Recent Articles
1.
Moussa D, Kirihara J, Ye Z, Fischer N, Khot J, Witthuhn B, et al.
J Dent Res
. 2019 Jul;
98(10):1112-1121.
PMID: 31313946
The evolution of bonded restorations has undergone great progress over several decades. Nonetheless, life spans of bonded restorations are limited mainly because of the eventual incidence of recurrent caries. Over...
2.
Fallon A, Baldridge G, Higgins L, Witthuhn B
In Vitro Cell Dev Biol Anim
. 2012 Dec;
49(1):66-73.
PMID: 23271364
The obligate intracellular bacterium, Wolbachia pipientis (Rickettsiales: Anaplasmataceae), distorts reproduction of its arthropod hosts to facilitate invasion of naïve populations. This property makes Wolbachia an attractive "gene drive" agent with...
3.
Witthuhn B, Bernlohr D
Cytokine
. 2001 Jun;
14(3):129-35.
PMID: 11396990
High-fat-fed C57Bl/6J FABP4/aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. FABP4/aP2 protein's function to bind fatty acids in the adipocytes may...
4.
Witthuhn B, Williams M, Kerawalla H, Uckun F
Leuk Lymphoma
. 1999 Feb;
32(3-4):289-97.
PMID: 10037026
Substrate recognition by Janus family protein tyrosine kinases was examined utilizing recombinant baculovirus produced components of the interleukin 2 receptor (IL2R) system i.e. Jak1, Transducers and Activators of Transcription (STAT)....
5.
Feng J, Witthuhn B, Matsuda T, Kohlhuber F, Kerr I, Ihle J
Mol Cell Biol
. 1997 May;
17(5):2497-501.
PMID: 9111318
The Janus protein tyrosine kinases (Jaks) play critical roles in transducing growth and differentiation signals emanating from ligand-activated cytokine receptor complexes. The activation of the Jaks is hypothesized to occur...
6.
Kohlhuber F, ROGERS N, Watling D, Feng J, Guschin D, Briscoe J, et al.
Mol Cell Biol
. 1997 Feb;
17(2):695-706.
PMID: 9001223
Cell lines that are mutated in interferon (IFN) responses have been critical in establishing an essential role for the JAK family of nonreceptor tyrosine kinases in interferon signalling. Mutant gamma1A...
7.
Witthuhn B, Faust C
Mol Immunol
. 1996 Jul;
33(10):881-90.
PMID: 8845020
The high affinity receptor for IgE, which mediates allergic reactions, is found exclusively on mast cells, basophils and epidermal Langerhans cells. It is composed of an alpha, beta and two...
8.
Briscoe J, ROGERS N, Witthuhn B, Watling D, Harpur A, Wilks A, et al.
EMBO J
. 1996 Feb;
15(4):799-809.
PMID: 8631301
The receptor-associated protein tyrosine kinases JAK1 and JAK2 are both required for the interferon (IFN)-gamma response. The effects of expressing kinase-negative JAK mutant proteins on signal transduction in response to...
9.
Nosaka T, Van Deursen J, Tripp R, Thierfelder W, Witthuhn B, McMickle A, et al.
Science
. 1995 Nov;
270(5237):800-2.
PMID: 7481769
The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and...
10.
Lai K, Jin Y, Graham D, Witthuhn B, Ihle J, Liu E
J Biol Chem
. 1995 Oct;
270(42):25028-36.
PMID: 7559633
Signal transduction of cytokine receptors is mediated by the JAK family of tyrosine kinases. Recently, the kinase partners for the interleukin (IL)-2 receptor have been identified as JAK1 and JAK3....