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B-Y Zeng

Explore the profile of B-Y Zeng including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 98
Followers 0
Related Specialties
Neurology
Physiology
Geriatrics
Top 10 Co-Authors
P Jenner
S Rose
R K B Pearce
B C Tel
A D Medhurst
C Cannizzaro
G McKenzie
B Halliwell
A Owen
M M Iravani
Published In
Neurosci Lett
J Neural Transm (Vienna)
Exp Neurol
Mech Ageing Dev
Neuroscience
Affiliations
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Recent Articles
1.
MPTP treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26S proteasome
Zeng B, Iravani M, Lin S, Irifune M, Kuoppamaki M, Al-Barghouthy G, et al.
Eur J Neurosci . 2006 Apr; 23(7):1766-74. PMID: 16623833
Dysfunction of the ubiquitin-proteasome system occurs in the substantia nigra (SN) in Parkinson's disease (PD). However, it is unknown whether this is a primary cause or a secondary consequence of...
2.
Proteasomal activity in brain differs between species and brain regions and changes with age
Zeng B, Medhurst A, Jackson M, Rose S, Jenner P
Mech Ageing Dev . 2005 May; 126(6-7):760-6. PMID: 15888331
Age-related increase in protein oxidation in brain coupled to an impairment of proteasomal activity may underline neuronal loss but differences in susceptibility between species and brain regions remain unexplained. We...
3.
Alterations in expression of dopamine receptors and neuropeptides in the striatum of GTP cyclohydrolase-deficient mice
Zeng B, Heales S, Canevari L, Rose S, Jenner P
Exp Neurol . 2004 Nov; 190(2):515-24. PMID: 15530890
The hph-1 mice have defective tetrahydrobiopterin biosynthesis and share many neurochemical similarities with l-dopa-responsive dystonia (DRD) in humans. In both, there are deficiencies in GTP cyclohydrolase I and low brain...
4.
Modafinil prevents the MPTP-induced increase in GABAA receptor binding in the internal globus pallidus of MPTP-treated common marmosets
Zeng B, Smith L, Pearce R, Tel B, Chancharme L, Moachon G, et al.
Neurosci Lett . 2003 Dec; 354(1):6-9. PMID: 14698469
The psychostimulant drug modafinil induces a reversal of motor deficits in MPTP treated primates and prevents MPTP toxicity to substantia nigra but its mechanism of action is not clear. In...
5.
Alterations in striatal neuropeptide mRNA produced by repeated administration of L-DOPA, ropinirole or bromocriptine correlate with dyskinesia induction in MPTP-treated common marmosets
Tel B, Zeng B, Cannizzaro C, Pearce R, Rose S, Jenner P
Neuroscience . 2002 Nov; 115(4):1047-58. PMID: 12453478
Chronic administration of L-DOPA to MPTP-treated common marmosets induces marked dyskinesia while repeated administration of equivalent antiparkisonian doses of ropinirole and bromocriptine produces only mild involuntary movements. The occurrence of...
6.
6-Hydroxydopamine lesioning differentially affects alpha-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats
Zeng B, Dass B, Owen A, Rose S, Cannizzaro C, Tel B, et al.
Neurosci Lett . 2002 Apr; 322(1):33-6. PMID: 11958837
The effect of a unilateral 6-hydroxydopamine (6-OHDA) lesion and/or repeated administration of levodopa (L-DOPA) to normal and 6-OHDA-lesioned rats on alpha-synuclein mRNA expression was investigated by in situ hybridization histochemistry....
7.
Chronic high dose L-DOPA alone or in combination with the COMT inhibitor entacapone does not increase oxidative damage or impair the function of the nigro-striatal pathway in normal cynomologus monkeys
Lyras L, Zeng B, McKenzie G, Pearce R, Halliwell B, Jenner P
J Neural Transm (Vienna) . 2002 Jan; 109(1):53-67. PMID: 11793162
Parkinson's disease (PD) is characterised by a loss of pigmented dopaminergic neurones in the zona compacta of substantia nigra. The mechanisms underlying nigral cell death remain unknown but may involve...