Ayuko Hoshino
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Explore the profile of Ayuko Hoshino including associated specialties, affiliations and a list of published articles.
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30
Citations
7967
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Recent Articles
1.
Hirosawa K, Sato Y, Kasai R, Yamaguchi E, Komura N, Ando H, et al.
Nat Commun
. 2025 Mar;
16(1):2419.
PMID: 40075063
Small extracellular vesicles (sEVs) play crucial roles in intercellular communication. However, the internalization of individual sEVs by recipient cells has not been directly observed. Here, we examined these mechanisms using...
2.
Bojmar L, Zambirinis C, Hernandez J, Chakraborty J, Shaashua L, Kim J, et al.
Nat Med
. 2024 Jun;
30(8):2170-2180.
PMID: 38942992
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to their metastatic risk, timing...
3.
Bojmar L, Kim H, Sugiura K, Heissel S, Lucotti S, Cioffi M, et al.
STAR Protoc
. 2023 Dec;
5(1):102754.
PMID: 38096060
Characterization of isolated extracellular vesicles and particles (EVPs) is crucial for determining functions and biomarker potential. Here, we present a protocol to analyze size, number, morphology, and EVP protein cargo...
4.
Uryu K, Soplop N, Sheahan T, Catanese M, Huynh C, Pena J, et al.
bioRxiv
. 2023 Oct;
PMID: 37808646
Scanning electron microscopy (SEM) offers an unparalleled view of the membrane topography of mammalian cells by using a conventional osmium (OsO) and ethanol-based tissue preparation. However, conventional SEM methods limit...
5.
Takemori A, Kaulich P, Konno R, Kawashima Y, Hamazaki Y, Hoshino A, et al.
Proteomics
. 2023 Aug;
24(3-4):e2200431.
PMID: 37548120
Middle-down proteomics (MDP) is an analytical approach in which protein samples are digested with proteases such as Glu-C to generate large peptides (>3 kDa) that are analyzed by mass spectrometry...
6.
7.
Kenari A, Bojmar L, Heissel S, Molina H, Lyden D, Hoshino A
Methods Mol Biol
. 2023 Feb;
2628:291-300.
PMID: 36781793
Plasma extracellular vesicles and particles (EVPs) are enriched in biomolecules that reflect individuals' physiological and pathological states. Several studies have demonstrated the potential of human plasma EVPs as a novel...
8.
Suwatthanarak T, Ito K, Tanaka M, Sugiura K, Hoshino A, Miyamoto Y, et al.
Biomater Adv
. 2023 Jan;
146:213283.
PMID: 36640525
As an organizer of multi-molecular membrane complexes, the tetraspanin CD9 has been implicated in a number of biological processes, including cancer metastasis, and is a candidate therapeutic target. Here, we...
9.
Khan I, Gril B, Hoshino A, Yang H, Lee M, Difilippantonio S, et al.
Clin Exp Metastasis
. 2022 Aug;
39(5):815-831.
PMID: 35939247
Tumor-derived exosomes have documented roles in accelerating the initiation and outgrowth of metastases, as well as in therapy resistance. Little information supports the converse, that exosomes or similar vesicles can...
10.
Sugiura K, Shimura H, Hoshino A
Brain Nerve
. 2021 Aug;
73(8):879-887.
PMID: 34376594
Exosomes, small bilayer vesicles secreted by all cells, are recognized as a novel communication tool among distant organs. They can cross the blood-brain barrier and be taken up by specific...