Ayman El-Guindy
Overview
Explore the profile of Ayman El-Guindy including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
499
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0
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Recent Articles
1.
Li J, Walsh A, Lam T, Delecluse H, El-Guindy A
PLoS Pathog
. 2019 Aug;
15(8):e1007980.
PMID: 31461506
Almost one third of herpesvirus proteins are expressed with late kinetics. Many of these late proteins serve crucial structural functions such as formation of virus particles, attachment to host cells...
2.
Li X, Kozlov S, El-Guindy A, Bhaduri-McIntosh S
J Virol
. 2019 Jun;
93(17).
PMID: 31189703
Herpesviruses are ubiquitous, and infection by some, like Epstein-Barr virus (EBV), is nearly universal. To persist, EBV must periodically switch from a latent to a replicative/lytic phase. This productive phase...
3.
Weber E, Buzovetsky O, Heston L, Yu K, Knecht K, El-Guindy A, et al.
J Virol
. 2019 May;
93(14).
PMID: 31068430
The pathogenesis of Epstein-Barr virus (EBV) infection, including development of lymphomas and carcinomas, is dependent on the ability of the virus to transit from latency to the lytic phase. This...
4.
Lyons D, Yu K, Vander Heiden J, Heston L, Dittmer D, El-Guindy A, et al.
J Virol
. 2018 Jul;
92(19).
PMID: 30021895
Epstein-Barr virus (EBV) ZEBRA protein activates the EBV lytic cycle. Cellular AP-1 proteins with alanine-to-serine [AP-1(A/S)] substitutions homologous to ZEBRA(S186) assume some functions of EBV ZEBRA. These AP-1(A/S) mutants bind...
5.
Racicot K, Aldo P, El-Guindy A, Kwon J, Romero R, Mor G
J Immunol
. 2017 Mar;
198(8):3029-3032.
PMID: 28264970
Pregnant women have greater mortality and complications associated with viral infections compared with the general population, but the reason for the increased susceptibility is not well defined. Placenta type I...
6.
McKenzie J, Lopez-Giraldez F, Delecluse H, Walsh A, El-Guindy A
PLoS Pathog
. 2016 Nov;
12(11):e1006008.
PMID: 27855219
Subversion of host immune surveillance is a crucial step in viral pathogenesis. Epstein-Barr virus (EBV) encodes two immune evasion gene products, BCRF1 (viral IL-10) and BPLF1 (deubiquitinase/deneddylase); both proteins suppress...
7.
Racicot K, Kwon J, Aldo P, Abrahams V, El-Guindy A, Romero R, et al.
Am J Reprod Immunol
. 2016 Feb;
75(4):451-60.
PMID: 26892235
Problem: Preterm birth (PTB) affects approximately 12% of pregnancies and at least 50% of cases have no known risk factors. We hypothesize that subclinical viral infections of the placenta are...
8.
McKenzie J, El-Guindy A
Curr Top Microbiol Immunol
. 2015 Oct;
391:237-61.
PMID: 26428377
Epstein-Barr virus, which mainly infects B cells and epithelial cells, has two modes of infection: latent and lytic. Epstein-Barr virus infection is predominantly latent; however, lytic infection is detected in...
9.
El-Guindy A, Lopez-Giraldez F, Delecluse H, McKenzie J, Miller G
PLoS Pathog
. 2014 Aug;
10(8):e1004307.
PMID: 25166506
The mechanism regulating expression of late genes, encoding viral structural components, is an unresolved problem in the biology of DNA tumor viruses. Here we show that BGLF4, the only protein...
10.
Park R, El-Guindy A, Heston L, Lin S, Yu K, Nagy M, et al.
PLoS One
. 2014 Apr;
9(4):e92593.
PMID: 24705134
Many viruses target cytoplasmic polyA binding protein (PABPC) to effect widespread inhibition of host gene expression, a process termed viral host-shutoff (vhs). During lytic replication of Epstein Barr Virus (EBV)...