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Ayache Bouakaz

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Articles 114
Citations 1173
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Recent Articles
1.
Presset A, Bodard S, Lefevre A, Millet A, Oujagir E, Dupuy C, et al.
Front Mol Neurosci . 2024 Dec; 17:1383963. PMID: 39634608
Microbubble (MB)-assisted ultrasound (US) is an innovative modality for the non-invasive, targeted, and efficient delivery of therapeutic molecules into the brain. Previously, we reported the first metabolomic signature of blood-brain...
2.
Radha R, Paul V, Anjum S, Bouakaz A, Pitt W, Husseini G
Sci Rep . 2024 May; 14(1):10499. PMID: 38714740
Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering the low bioavailability, high cytotoxicity, and undesirable side effects of some clinical drugs. Targeted delivery and sustained...
3.
Bouakaz A, Michel Escoffre J
Adv Drug Deliv Rev . 2024 Feb; 206:115199. PMID: 38325561
Ultrasound mediated drug delivery, a promising therapeutic modality, has evolved remarkably over the past three decades. Initially designed to enhance contrast in ultrasound imaging, microbubbles have emerged as a main...
4.
Chen J, Escoffre J, Romito O, Iazourene T, Presset A, Roy M, et al.
Ultrason Sonochem . 2024 Jan; 103:106768. PMID: 38241945
The blood-brain barrier (BBB) maintains brain homeostasis, regulates influx and efflux transport, and provides protection to the brain tissue. Ultrasound (US) and microbubble (MB)-mediated blood-brain barrier opening is an effective...
5.
Qiao X, Zhang R, Yu J, Yan Y, Bouakaz A, Su X, et al.
Ultrasonics . 2024 Jan; 138:107244. PMID: 38237398
Fractional flow has been proposed for quantifying the degree of functional stenosis in cerebral arteries. Herein, subharmonic aided pressure estimation (SHAPE) combined with plane wave (PW) transmission was employed to...
6.
Roy M, Alix C, Burlaud-Gaillard J, Fouan D, Raoul W, Bouakaz A, et al.
Mol Pharm . 2024 Jan; 21(2):831-844. PMID: 38174896
Tumor spheroids are promising three-dimensional (3D) tumor models for the evaluation of drug delivery methods. The design of noninvasive and targeted drug methods is required to improve the intratumoral bioavailability...
7.
Micaletti F, Escoffre J, Kerneis S, Bouakaz A, Galvin 3rd J, Boullaud L, et al.
Adv Drug Deliv Rev . 2023 Dec; 204:115145. PMID: 38042259
Treating pathologies of the inner ear is a major challenge. To date, a wide range of procedures exists for administering therapeutic agents to the inner ear, with varying degrees of...
8.
Cao F, Zhang J, Li D, Wang M, Lai C, Xu T, et al.
IEEE Trans Biomed Eng . 2023 Apr; 70(6):1869-1878. PMID: 37015531
Objective: We applied the method of non-invasive ultrasound (US) neuromodulation to regulate blood pressure (BP) by stimulating the solitary tract nucleus (NTS) of spontaneously hypertensive rats (SHRs). Methods: The rats...
9.
Roy M, Alix C, Bouakaz A, Serriere S, Escoffre J
Pharmaceutics . 2023 Mar; 15(3). PMID: 36986667
Tumor spheroids as well as multicellular tumor spheroids (MCTSs) are promising 3D in vitro tumor models for drug screening, drug design, drug targeting, drug toxicity, and validation of drug delivery...
10.
Li D, Cao F, Han J, Wang M, Lai C, Zhang J, et al.
J Hypertens . 2023 Mar; 41(5):852-866. PMID: 36883470
Objective: In this study, we aimed to investigate the sustainable antihypertensive effects and protection against target organ damage caused by low-intensity focused ultrasound (LIFU) stimulation and the underlying mechanism in...