Axel Schweickert
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Explore the profile of Axel Schweickert including associated specialties, affiliations and a list of published articles.
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36
Citations
1126
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Recent Articles
1.
Szenker-Ravi E, Ott T, Yusof A, Chopra M, Khatoo M, Pak B, et al.
Am J Hum Genet
. 2025 Jan;
112(2):353-373.
PMID: 39753129
Four genes-DAND5, PKD1L1, MMP21, and CIROP-form a genetic module that has specifically evolved in vertebrate species that harbor motile cilia in their left-right organizer (LRO). We find here that CIROZ...
2.
Tisler M, Ott T, Blum M, Schweickert A
MicroPubl Biol
. 2023 Aug;
2023.
PMID: 37649557
Histone deacetylases (HDACs) are key posttranslational modulators of the proteome. We show that expression of ( ) is dynamic and appears in a tissue specific manner throughout embryonic development of...
3.
Tingler M, Brugger A, Feistel K, Schweickert A
Front Cell Dev Biol
. 2022 Jul;
10:858272.
PMID: 35813209
The vertebrate left-right axis is specified during neurulation by events occurring in a transient ciliated epithelium termed left-right organizer (LRO), which is made up of two distinct cell types. In...
4.
Maerker M, Getwan M, Dowdle M, McSheene J, Gonzalez V, Pelliccia J, et al.
Nat Commun
. 2021 Sep;
12(1):5482.
PMID: 34531379
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at the left LRO margin. Ciliary activity of the calcium channel Pkd2...
5.
Kurrle Y, Kunesch K, Bogusch S, Schweickert A
Genesis
. 2019 Nov;
58(2):e23344.
PMID: 31705622
Mucus secretion and ciliary motility are hallmarks for muco-ciliary epithelia (MCE). Both, mammalian airways as well as the less complex epidermis of Xenopus embryos show cilia-driven mucus flow to protect...
6.
Schneider I, Kreis J, Schweickert A, Blum M, Vick P
Development
. 2019 May;
146(9).
PMID: 31036544
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal signaling. Nodal asymmetry is established by a leftward fluid-flow generated at the ciliated...
7.
Vick P, Kreis J, Schneider I, Tingler M, Getwan M, Thumberger T, et al.
iScience
. 2018 Nov;
2:76-85.
PMID: 30428378
Nodal signaling controls asymmetric organ placement during vertebrate embryogenesis. Nodal is induced by a leftward fluid flow at the ciliated left-right organizer (LRO). The mechanism of flow sensing, however, has...
8.
Tingler M, Kurz S, Maerker M, Ott T, Fuhl F, Schweickert A, et al.
Curr Biol
. 2018 Feb;
28(5):810-816.e3.
PMID: 29478852
Anatomical and functional asymmetries are widespread in the animal kingdom [1, 2]. In vertebrates, many visceral organs are asymmetrically placed [3]. In snails, shells and inner organs coil asymmetrically, and...
9.
Schweickert A, Ott T, Kurz S, Tingler M, Maerker M, Fuhl F, et al.
J Cardiovasc Dev Dis
. 2018 Jan;
5(1).
PMID: 29367579
Laterality of inner organs is a wide-spread characteristic of vertebrates and beyond. It is ultimately controlled by the left-asymmetric activation of the Nodal signaling cascade in the lateral plate mesoderm...
10.
Ulmer B, Tingler M, Kurz S, Maerker M, Andre P, Monch D, et al.
Sci Rep
. 2017 Feb;
7:43010.
PMID: 28220837
Goosecoid (Gsc) expression marks the primary embryonic organizer in vertebrates and beyond. While functions have been assigned during later embryogenesis, the role of Gsc in the organizer has remained enigmatic....