Axel Martinelli
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Explore the profile of Axel Martinelli including associated specialties, affiliations and a list of published articles.
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Articles
37
Citations
848
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Recent Articles
1.
Zito A, Martinelli A, Masiero M, Akhmedov M, Akhmedov M, Kwee I
Bioinformatics
. 2025 Feb;
PMID: 39999010
Motivation: Batch effects (BEs) are a predominant source of noise in omics data and often mask real biological signals. BEs remain common in existing datasets. Current methods for BE correction...
2.
Cassiano G, Martinelli A, Mottin M, Neves B, Andrade C, Ferreira P, et al.
Front Cell Infect Microbiol
. 2024 Mar;
14:1353057.
PMID: 38495651
Introduction: The global evolution of resistance to Artemisinin-based Combination Therapies (ACTs) by malaria parasites, will severely undermine our ability to control this devastating disease. Methods: Here, we have used whole...
3.
Kwee I, Martinelli A, Khayal L, Akhmedov M
Bioinform Adv
. 2023 Jan;
2(1):vbac064.
PMID: 36699415
Summary: Accessing the collection of perturbed gene expression profiles, such as the LINCS L1000 connectivity map, is usually performed at the individual dataset level, followed by a summary performed by...
4.
Maseng M, Tawe L, Thami P, Seatla K, Moyo S, Martinelli A, et al.
Pharmgenomics Pers Med
. 2021 Mar;
14:335-347.
PMID: 33758532
Purpose: CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) regimens for HIV-infected individuals. Polymorphisms of the gene...
5.
Akhmedov M, Martinelli A, Geiger R, Kwee I
NAR Genom Bioinform
. 2021 Feb;
2(1):lqz019.
PMID: 33575569
As the cost of sequencing drops rapidly, the amount of 'omics data increases exponentially, making data visualization and interpretation-'tertiary' analysis a bottleneck. Specialized analytical tools requiring technical expertise are available....
6.
Doyle S, Tracey A, Laing R, Holroyd N, Bartley D, Bazant W, et al.
Commun Biol
. 2020 Nov;
3(1):656.
PMID: 33168940
Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode model for studying anthelmintic resistance and other parasite-specific traits among...
7.
Marks N, Winter A, Gu H, Maitland K, Gillan V, Ambroz M, et al.
Sci Rep
. 2019 Nov;
9(1):17594.
PMID: 31772378
Parasitic nematodes transition between dramatically different free-living and parasitic stages, with correctly timed development and migration crucial to successful completion of their lifecycle. However little is known of the mechanisms...
8.
Rezansoff A, Laing R, Martinelli A, Stasiuk S, Redman E, Bartley D, et al.
Int J Parasitol
. 2019 Sep;
49(11):847-858.
PMID: 31525371
Differential expression analysis between parasitic nematode strains is commonly used to implicate candidate genes in anthelmintic resistance or other biological functions. We have tested the hypothesis that the high genetic...
9.
Carr M, Gonzalez G, Martinelli A, Wastika C, Ito K, Orba Y, et al.
Virus Genes
. 2019 Jul;
55(5):630-642.
PMID: 31292858
Japanese encephalitis virus (JEV) exerts a profound burden of viral encephalitis. We have investigated the differentially expressed transcripts in the neuronal transcriptome during JEV infection by RNA sequencing (RNA-Seq) of...
10.
Doyle S, Illingworth C, Laing R, Bartley D, Redman E, Martinelli A, et al.
BMC Genomics
. 2019 Mar;
20(1):218.
PMID: 30876405
Background: Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number...