Axel F Brilot
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Explore the profile of Axel F Brilot including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
1600
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Recent Articles
1.
Park J, Bartzoka F, von Beck T, Li Z, Mishina M, Hebert L, et al.
Lancet Microbe
. 2024 Dec;
6(2):100935.
PMID: 39667375
Background: Egg-based inactivated quadrivalent seasonal influenza vaccine (eIIV4), cell culture-based inactivated quadrivalent seasonal influenza vaccine (ccIIV4), and recombinant haemagglutinin (HA)-based quadrivalent seasonal influenza vaccine (RIV4) have been licensed for use...
2.
Nieweglowska E, Brilot A, Mendez-Moran M, Kokontis C, Baek M, Li J, et al.
Nat Commun
. 2023 Feb;
14(1):927.
PMID: 36807264
To protect themselves from host attack, numerous jumbo bacteriophages establish a phage nucleus-a micron-scale, proteinaceous structure encompassing the replicating phage DNA. Bacteriophage and host proteins associated with replication and transcription...
3.
Remesh S, Merz G, Brilot A, Chio U, Rizo A, Pospiech Jr T, et al.
Structure
. 2023 Feb;
31(3):253-264.e6.
PMID: 36805129
The SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor-binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered the SARS-CoV-2 host entry receptor,...
4.
Remesh S, Merz G, Brilot A, Chio U, Rizo A, Pospiech Jr T, et al.
bioRxiv
. 2022 Aug;
PMID: 35982665
The SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered the SARS-CoV-2 host entry...
5.
Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, et al.
Res Sq
. 2021 May;
PMID: 34031651
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report...
6.
Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, et al.
bioRxiv
. 2021 May;
PMID: 34013269
The SARS-CoV-2 protein Nsp2 has been implicated in a wide range of viral processes, but its exact functions, and the structural basis of those functions, remain unknown. Here, we report...
7.
CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation
Brilot A, Lyon A, Zelter A, Viswanath S, Maxwell A, MacCoss M, et al.
Elife
. 2021 May;
10.
PMID: 33949948
Microtubule (MT) nucleation is regulated by the γ-tubulin ring complex (γTuRC), conserved from yeast to humans. In , γTuRC is composed of seven identical γ-tubulin small complex (γTuSC) sub-assemblies, which...
8.
Schoof M, Faust B, Saunders R, Sangwan S, Rezelj V, Hoppe N, et al.
Science
. 2020 Nov;
370(6523):1473-1479.
PMID: 33154106
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters host cells via an interaction between its Spike protein and the host cell receptor angiotensin-converting enzyme 2 (ACE2). By screening...
9.
Gordon D, Hiatt J, Bouhaddou M, Rezelj V, Ulferts S, Braberg H, et al.
Science
. 2020 Oct;
370(6521).
PMID: 33060197
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more...
10.
Li Q, Pellegrino J, Lee D, Tran A, Chaires H, Wang R, et al.
Nature
. 2020 Sep;
586(7827):145-150.
PMID: 32968273
Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that...