Axel A Neumann
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Explore the profile of Axel A Neumann including associated specialties, affiliations and a list of published articles.
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18
Citations
1393
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Recent Articles
1.
Sobinoff A, Allen J, Neumann A, Yang S, Walsh M, Henson J, et al.
EMBO J
. 2017 Sep;
36(19):2907-2919.
PMID: 28877996
Alternative lengthening of telomeres (ALT) is a telomere lengthening pathway that predominates in aggressive tumors of mesenchymal origin; however, the underlying mechanism of telomere synthesis is not fully understood. Here,...
2.
Dagg R, Pickett H, Neumann A, Napier C, Henson J, Teber E, et al.
Cell Rep
. 2017 Jun;
19(12):2544-2556.
PMID: 28636942
Acquisition of replicative immortality is currently regarded as essential for malignant transformation. This is achieved by activating a telomere lengthening mechanism (TLM), either telomerase or alternative lengthening of telomeres, to...
3.
Neumann A, Watson C, Noble J, Pickett H, Tam P, Reddel R
Genes Dev
. 2013 Jan;
27(1):18-23.
PMID: 23307865
Some cancers use alternative lengthening of telomeres (ALT), a mechanism whereby new telomeric DNA is synthesized from a DNA template. To determine whether normal mammalian tissues have ALT activity, we...
4.
Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells
Conomos D, Stutz M, Hills M, Neumann A, Bryan T, Reddel R, et al.
J Cell Biol
. 2012 Dec;
199(6):893-906.
PMID: 23229897
Telomeres in cells that use the recombination-mediated alternative lengthening of telomeres (ALT) pathway elicit a DNA damage response that is partly independent of telomere length. We therefore investigated whether ALT...
5.
Bender H, Murchison E, Pickett H, Deakin J, Strong M, Conlan C, et al.
PLoS One
. 2012 Oct;
7(9):e46195.
PMID: 23049977
Telomeres, specialised structures that protect chromosome ends, play a critical role in preserving chromosome integrity. Telomere dynamics in the Tasmanian devil (Sarcophilus harrisii) are of particular interest in light of...
6.
Kaul Z, Cesare A, Huschtscha L, Neumann A, Reddel R
EMBO Rep
. 2011 Dec;
13(1):52-9.
PMID: 22157895
Replicative senescence is accompanied by a telomere-specific DNA damage response (DDR). We found that DDR+ telomeres occur spontaneously in early-passage normal human cells and increase in number with increasing cumulative...
7.
Pickett H, Henson J, Au A, Neumann A, Reddel R
Hum Mol Genet
. 2011 Sep;
20(23):4684-92.
PMID: 21903669
In human cancer cells with telomeres that have been over-lengthened by exogenous telomerase activity, telomere shortening can occur by a process that generates circles of double-stranded telomeric DNA (t-circles). Here,...
8.
Cesare A, Kaul Z, Cohen S, Napier C, Pickett H, Neumann A, et al.
Nat Struct Mol Biol
. 2009 Nov;
16(12):1244-51.
PMID: 19935685
Telomere dysfunction is typically studied under conditions in which a component of the six-subunit shelterin complex that protects chromosome ends is disrupted. The nature of spontaneous telomere dysfunction is less...
9.
Pickett H, Cesare A, Johnston R, Neumann A, Reddel R
EMBO J
. 2009 Feb;
28(7):799-809.
PMID: 19214183
Telomere lengths are maintained in many cancer cells by the ribonucleoprotein enzyme telomerase but can be further elongated by increasing telomerase activity through the overexpression of telomerase components. We report...
10.
Muntoni A, Neumann A, Hills M, Reddel R
Hum Mol Genet
. 2008 Dec;
18(6):1017-27.
PMID: 19095716
Alternative lengthening of telomeres (ALT) is a telomere length maintenance mechanism based on recombination, where telomeres use other telomeric DNA as a template for DNA synthesis. About 10% of all...