Austin E Gillen
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Explore the profile of Austin E Gillen including associated specialties, affiliations and a list of published articles.
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48
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1649
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Recent Articles
1.
Chamberlin J, Gillen A, Quinlan A
NAR Genom Bioinform
. 2024 Dec;
6(4):lqae175.
PMID: 39703419
Prevailing poly(dT)-primed 3' single-cell RNA-seq protocols generate barcoded cDNA fragments containing the reverse transcriptase priming site or in principle the polyadenylation site. Direct sequencing across this site was historically difficult...
2.
Ohlstrom D, Walker Z, Pandey A, Davis L, Engel K, Pan Z, et al.
Cancer Res Commun
. 2024 Dec;
5(1):106-118.
PMID: 39699274
scRNA-seq was used to study a patient with high-risk multiple myeloma featuring LCE. LCE was rooted in a transcriptomic subpopulation that corresponded to a genetic subclone and established novel links...
3.
Burtis A, DeNicola D, Ferguson M, Santos R, Pinilla C, Kriss M, et al.
Hepatology
. 2024 Jul;
81(2):591-608.
PMID: 39047085
Background And Aims: Chronic liver disease due to metabolic dysfunction-associated steatohepatitis (MASH) is a rapidly increasing global epidemic. MASH progression is a consequence of the complex interplay between inflammatory insults...
4.
Chamberlin J, Gillen A, Quinlan A
bioRxiv
. 2024 Jul;
PMID: 39026715
Prevailing poly(dT)-primed 3' single-cell RNA-seq protocols generate barcoded cDNA fragments containing the reverse transcriptase priming site, which is expected to be the poly(A) tail or a genomic adenine homopolymer. Direct...
5.
Sheth A, Althoff M, Tolison H, Engel K, Amaya M, Krug A, et al.
Cancer Discov
. 2024 May;
14(10):1922-1939.
PMID: 38787341
Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2, creating a therapeutic opportunity to target LSCs...
6.
Burtis A, DeNicola D, Ferguson M, Santos R, Pinilla C, Kriss M, et al.
bioRxiv
. 2024 Apr;
PMID: 38562766
Background And Aims: Chronic liver disease due to metabolic dysfunction-associated steatohepatitis (MASH) is a rapidly increasing global epidemic. MASH progression is a consequence of the complex interplay between inflammatory insults...
7.
Zhang X, Song B, Carlino M, Li G, Ferchen K, Chen M, et al.
Nat Immunol
. 2024 Mar;
25(4):703-715.
PMID: 38514887
Analysis of the human hematopoietic progenitor compartment is being transformed by single-cell multimodal approaches. Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) enables coupled surface protein and transcriptome profiling,...
8.
Pei S, Shelton I, Gillen A, Stevens B, Gasparetto M, Wang Y, et al.
Cancer Discov
. 2023 Jun;
13(9):2032-2049.
PMID: 37358260
Significance: These studies identify and characterize a new type of human acute myeloid LSC that is responsible for monocytic disease progression in patients with AML treated with venetoclax-based regimens. Our...
9.
Campbell A, Dyle M, Albanese R, Matheny T, Sudheendran K, Cortazar M, et al.
Cell Rep
. 2023 Jun;
42(6):112642.
PMID: 37314931
Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, whether loss of NMD results in widespread production...
10.
Gillen A, Epperson L, Orlicky D, Fu R, Martin S
Physiol Genomics
. 2023 Feb;
55(4):155-167.
PMID: 36847440
Hibernation is a natural model of extreme physiology in a mammal. Throughout winter, small hibernators repeatedly undergo rapid, dramatic swings in body temperature, perfusion, and oxygen delivery. To gain insight...