Aurelien Rappailles
Overview
Explore the profile of Aurelien Rappailles including associated specialties, affiliations and a list of published articles.
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8
Citations
401
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Recent Articles
1.
Hyrien O, Rappailles A, Guilbaud G, Baker A, Chen C, Goldar A, et al.
J Mol Biol
. 2013 Oct;
425(23):4673-89.
PMID: 24095859
The Replicon Theory proposed 50 years ago has proven to apply for replicons of the three domains of life. Here, we review our knowledge of genome organization into single and...
2.
Audit B, Baker A, Chen C, Rappailles A, Guilbaud G, Julienne H, et al.
Nat Protoc
. 2012 Dec;
8(1):98-110.
PMID: 23237832
In this protocol, we describe the use of the LastWave open-source signal-processing command language (http://perso.ens-lyon.fr/benjamin.audit/LastWave/) for analyzing cellular DNA replication timing profiles. LastWave makes use of a multiscale, wavelet-based signal-processing...
3.
Baker A, Audit B, Chen C, Moindrot B, Leleu A, Guilbaud G, et al.
PLoS Comput Biol
. 2012 Apr;
8(4):e1002443.
PMID: 22496629
In higher eukaryotes, replication program specification in different cell types remains to be fully understood. We show for seven human cell lines that about half of the genome is divided...
4.
Guilbaud G, Rappailles A, Baker A, Chen C, Arneodo A, Goldar A, et al.
PLoS Comput Biol
. 2012 Jan;
7(12):e1002322.
PMID: 22219720
Genome-wide replication timing studies have suggested that mammalian chromosomes consist of megabase-scale domains of coordinated origin firing separated by large originless transition regions. Here, we report a quantitative genome-wide analysis...
5.
Chen C, Duquenne L, Audit B, Guilbaud G, Rappailles A, Baker A, et al.
Mol Biol Evol
. 2011 Mar;
28(8):2327-37.
PMID: 21368316
During evolution, mutations occur at rates that can differ between the two DNA strands. In the human genome, nucleotide substitutions occur at different rates on the transcribed and non-transcribed strands...
6.
Chen C, Rappailles A, Duquenne L, Huvet M, Guilbaud G, Farinelli L, et al.
Genome Res
. 2010 Jan;
20(4):447-57.
PMID: 20103589
Neutral nucleotide substitutions occur at varying rates along genomes, and it remains a major issue to unravel the mechanisms that cause these variations and to analyze their evolutionary consequences. Here,...
7.
Dejardin J, Rappailles A, Cuvier O, Grimaud C, Decoville M, Locker D, et al.
Nature
. 2005 Mar;
434(7032):533-8.
PMID: 15791260
Polycomb and trithorax group (PcG and trxG) proteins maintain silent and active transcriptional states, respectively, throughout development. In Drosophila, PcG and trxG proteins associate with DNA regions named Polycomb and...
8.
Rappailles A, Decoville M, Locker D
Biol Cell
. 2004 Dec;
97(10):779-85.
PMID: 15610064
Background Information: The Pc-G (Polycomb group) and trx-G (trithorax group) genes play a key role in the regulation of the homoeotic genes. The homoeotic gene Scr (Sex combs reduced) contained...