Atif Shahab
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Explore the profile of Atif Shahab including associated specialties, affiliations and a list of published articles.
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9483
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Recent Articles
1.
Hallwirth C, Garg G, Peters T, Kramer B, Malani N, Hyman J, et al.
Mol Ther Methods Clin Dev
. 2015 Jun;
2:15015.
PMID: 26029726
Unequivocal demonstration of the therapeutic utility of γ-retroviral vectors for gene therapy applications targeting the hematopoietic system was accompanied by instances of insertional mutagenesis. These events stimulated the ongoing development...
2.
Nagarajan N, Bertrand D, Hillmer A, Zang Z, Yao F, Jacques P, et al.
Genome Biol
. 2012 Dec;
13(12):R115.
PMID: 23237666
Background: Gastric cancer is the second highest cause of global cancer mortality. To explore the complete repertoire of somatic alterations in gastric cancer, we combined massively parallel short read and...
3.
Yao F, Ariyaratne P, Hillmer A, Lee W, Li G, Teo A, et al.
PLoS One
. 2012 Oct;
7(9):e46152.
PMID: 23029419
Structural variations (SVs) contribute significantly to the variability of the human genome and extensive genomic rearrangements are a hallmark of cancer. While genomic DNA paired-end-tag (DNA-PET) sequencing is an attractive...
4.
Djebali S, Davis C, Merkel A, Dobin A, Lassmann T, Mortazavi A, et al.
Nature
. 2012 Sep;
489(7414):101-8.
PMID: 22955620
Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not...
5.
Ng K, Hillmer A, Chuah C, Juan W, Ko T, Teo A, et al.
Nat Med
. 2012 Mar;
18(4):521-8.
PMID: 22426421
Tyrosine kinase inhibitors (TKIs) elicit high response rates among individuals with kinase-driven malignancies, including chronic myeloid leukemia (CML) and epidermal growth factor receptor-mutated non-small-cell lung cancer (EGFR NSCLC). However, the...
6.
Handoko L, Xu H, Li G, Ngan C, Chew E, Schnapp M, et al.
Nat Genet
. 2011 Jun;
43(7):630-8.
PMID: 21685913
Mammalian genomes are viewed as functional organizations that orchestrate spatial and temporal gene regulation. CTCF, the most characterized insulator-binding protein, has been implicated as a key genome organizer. However, little...
7.
Hillmer A, Yao F, Inaki K, Lee W, Ariyaratne P, Teo A, et al.
Genome Res
. 2011 Apr;
21(5):665-75.
PMID: 21467267
Somatic genome rearrangements are thought to play important roles in cancer development. We optimized a long-span paired-end-tag (PET) sequencing approach using 10-Kb genomic DNA inserts to study human genome structural...
8.
Inaki K, Hillmer A, Ukil L, Yao F, Woo X, Vardy L, et al.
Genome Res
. 2011 Apr;
21(5):676-87.
PMID: 21467264
Using a long-span, paired-end deep sequencing strategy, we have comprehensively identified cancer genome rearrangements in eight breast cancer genomes. Herein, we show that 40%-54% of these structural genomic rearrangements result...
9.
Eshaghi M, Zhu L, Chu Z, Li J, Chan C, Shahab A, et al.
Eukaryot Cell
. 2010 Nov;
10(1):130-41.
PMID: 21076007
MBF (or DSC1) is known to regulate transcription of a set of G(1)/S-phase genes encoding proteins involved in regulation of DNA replication. Previous studies have shown that MBF binds not...
10.
Wu H, Tao J, Chen P, Shahab A, Ge W, Hart R, et al.
Proc Natl Acad Sci U S A
. 2010 Oct;
107(42):18161-6.
PMID: 20921386
MicroRNAs (miRNAs) are a class of small, noncoding RNAs that function as posttranscriptional regulators of gene expression. Many miRNAs are expressed in the developing brain and regulate multiple aspects of...