Astrid Musnier
Overview
Explore the profile of Astrid Musnier including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
172
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Recent Articles
1.
Musnier A, Bourquard T, Vallet A, Mathias L, Bruneau G, Ayoub M, et al.
Int J Mol Sci
. 2022 Sep;
23(17).
PMID: 36077163
Developing a therapeutic antibody is a long, tedious, and expensive process. Many obstacles need to be overcome, such as biophysical properties (issues of solubility, stability, weak production yields, etc.), as...
2.
Ugamraj H, Dang K, Ouisse L, Buelow B, Chini E, Castello G, et al.
MAbs
. 2022 Jul;
14(1):2095949.
PMID: 35867844
Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolize nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide. Other substrates...
3.
Tahir S, Bourquard T, Musnier A, Jullian Y, Corde Y, Omahdi Z, et al.
MAbs
. 2021 Aug;
13(1):1961349.
PMID: 34432559
MAbTope is a docking-based method for the determination of epitopes. It has been used to successfully determine the epitopes of antibodies with known 3D structures. However, during the antibody discovery...
4.
Granel J, Lemoine R, Morello E, Gallais Y, Mariot J, Drapeau M, et al.
Front Immunol
. 2020 Oct;
11:573040.
PMID: 33101296
Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase. PR3-ANCA binding to...
5.
Lanotte R, Garambois V, Gaborit N, Larbouret C, Musnier A, Martineau P, et al.
Cancer Sci
. 2020 May;
111(7):2508-2525.
PMID: 32415868
Human epidermal growth factor receptor 4 (HER4) isoforms have oncogenic or tumor suppressor functions depending on their susceptibility to proteolytic cleavage and HER4 intracellular domain (4ICD) translocation. Here, we report...
6.
Bourquard T, Musnier A, Trefier A, Landomiel F, Boulo T, Reiter E, et al.
Methods Mol Biol
. 2019 Mar;
1957:177-194.
PMID: 30919355
β-arrestins are so-called hub proteins: they make complexes with many different partners, assembling functional complexes, and thereby fulfilling their biological function. The importance of this process in G protein-coupled receptor...
7.
Bourquard T, Musnier A, Puard V, Tahir S, Ayoub M, Jullian Y, et al.
J Immunol
. 2018 Oct;
201(10):3096-3105.
PMID: 30322966
Abs are very efficient drugs, ∼70 of them are already approved for medical use, over 500 are in clinical development, and many more are in preclinical development. One important step...
8.
Trefier A, Pellissier L, Musnier A, Reiter E, Guillou F, Crepieux P
Front Endocrinol (Lausanne)
. 2018 Feb;
9:17.
PMID: 29456523
G protein-coupled receptors (GPCRs) exert their physiological function by transducing a complex signaling network that coordinates gene expression and dictates the phenotype of highly differentiated cells. Much is known about...
9.
Trefier A, Musnier A, Landomiel F, Bourquard T, Boulo T, Ayoub M, et al.
FASEB J
. 2017 Nov;
32(3):1154-1169.
PMID: 29084767
Many interaction partners of β-arrestins intervene in the control of mRNA translation. However, how β-arrestins regulate this cellular process has been poorly explored. In this study, we show that β-arrestins...
10.
Reiter E, Ayoub M, Pellissier L, Landomiel F, Musnier A, Trefier A, et al.
Mol Cell Endocrinol
. 2017 Feb;
449:28-41.
PMID: 28174117
G protein-coupled receptors (GPCRs) play crucial roles in the ability of target organs to respond to hormonal cues. GPCRs' activation mechanisms have long been considered as a two-state process connecting...