Assaf Marcus
Overview
Explore the profile of Assaf Marcus including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
742
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Recent Articles
1.
Nicolai C, Wolf N, Chang I, Kirn G, Marcus A, Ndubaku C, et al.
Sci Immunol
. 2020 Mar;
5(45).
PMID: 32198222
Several immunotherapy approaches that mobilize CD8 T cell responses stimulate tumor rejection, and some, such as checkpoint blockade, have been approved for several cancer indications and show impressive increases in...
2.
Marcus A, Mao A, Lensink-Vasan M, Wang L, Vance R, Raulet D
Immunity
. 2018 Oct;
49(4):754-763.e4.
PMID: 30332631
Detection of cytosolic DNA by the enzyme cGAS triggers the production of cGAMP, a second messenger that binds and activates the adaptor protein STING, which leads to interferon (IFN) production....
3.
Raulet D, Marcus A, Coscoy L
Immunol Rev
. 2017 Oct;
280(1):93-101.
PMID: 29027233
Natural killer (NK) cells recognize and kill cancer cells and infected cells by engaging cell surface ligands that are induced preferentially or exclusively on these cells. These ligands are recognized...
4.
Bose D, Su Y, Marcus A, Raulet D, Hammond M
Cell Chem Biol
. 2016 Nov;
23(12):1539-1549.
PMID: 27889408
In mammalian cells, the second messenger (2'-5',3'-5') cyclic guanosine monophosphate-adenosine monophosphate (2',3'-cGAMP), is produced by the cytosolic DNA sensor cGAMP synthase (cGAS), and subsequently bound by the stimulator of interferon...
5.
Iannello A, Thompson T, Ardolino M, Marcus A, Raulet D
Curr Opin Immunol
. 2015 Dec;
38:52-8.
PMID: 26686774
Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing...
6.
Marcus A, Eshhar Z
Expert Opin Biol Ther
. 2014 Mar;
14(7):947-54.
PMID: 24661086
Introduction: Chimeric antigen (or antibody) receptors (CAR) are fusion proteins typically combining an antibody-derived targeting fragment with signaling domains capable of activating immune cells. Recent clinical trials have shown the...
7.
Marcus A, Gowen B, Thompson T, Iannello A, Ardolino M, Deng W, et al.
Adv Immunol
. 2014 Feb;
122:91-128.
PMID: 24507156
In recent years, roles of the immune system in immune surveillance of cancer have been explored using a variety of approaches. The roles of the adaptive immune system have been...
8.
Marcus A, Raulet D
Curr Biol
. 2013 Sep;
23(17):R817-20.
PMID: 24028966
Natural killer (NK) cells are generally considered to be part of the innate immune system. Over the past few years, however, evidence has accumulated suggesting that NK cells have certain...
9.
10.
Marcus A, Eshhar Z
Expert Opin Biol Ther
. 2011 Oct;
11(12):1551-4.
PMID: 21995504
Adoptive cell transfer (ACT) therapy involves transfer of therapeutic lymphocytes to patients mostly for the treatment of cancer and viral infections. One modality to generate therapeutic lymphocytes is to genetically...