Ashley A Kelly
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Explore the profile of Ashley A Kelly including associated specialties, affiliations and a list of published articles.
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12
Citations
195
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Recent Articles
1.
Yu W, Hegarty J, Berg A, Kelly A, Wang Y, Poritz L, et al.
Dis Markers
. 2012 Mar;
32(2):83-91.
PMID: 22377701
PTPN2 is a risk gene for Crohn's disease (CD). We investigated whether PTPN2 genetic variants (rs2542151 and rs2542152) were associated with CD in a familial IBD registry. Both rs2542151 and...
2.
Lin Z, Hegarty J, Berb A, Wang Z, Kelly A, Wang Y, et al.
Swiss Med Wkly
. 2011 Nov;
141:w13290.
PMID: 22065243
Background And Purpose: The SNP R30Q (rs1248696) within the discs large homolog 5 (DLG5) gene has been associated with inflammatory bowel disease (IBD). In this study, we examined the genetic...
3.
Yu W, Lin Z, Hegarty J, Chen X, Kelly A, Wang Y, et al.
Inflammation
. 2011 Oct;
35(3):889-99.
PMID: 21968973
Ulcerative colitis (UC) and Crohn's disease (CD) are two related yet different forms of chronic intestinal inflammation. We investigated the genes regulated by NKX2-3 in B cells from a UC...
4.
John G, Hegarty J, Yu W, Berg A, Pastor D, Kelly A, et al.
Mol Genet Metab
. 2011 Aug;
104(1-2):174-9.
PMID: 21803625
NKX2-3 SNP rs11190140 is associated with inflammatory bowel disease (IBD). The T allele is over-transmitted in IBD and the C allele represents a potential CpG methylation site. We hypothesize that...
5.
Lin Z, John G, Hegarty J, Berg A, Yu W, Wang Y, et al.
Ann Hum Genet
. 2011 Jul;
75(5):559-68.
PMID: 21790524
Surfactant protein-D (SP-D) is expressed on mucosal surfaces and functions in the innate immune response to microorganisms. We studied the genetic association of the two nonsynonymous SP-D single nucleotide polymorphisms...
6.
Poritz L, Harris 3rd L, Kelly A, Koltun W
Dig Dis Sci
. 2011 Jul;
56(10):2802-9.
PMID: 21748286
Background And Aims: Studies have shown a decrease in key tight junction (TJ) proteins such as ZO-1 and occludin in both inflammatory bowel disease (IBD) and experimental models of inflammation....
7.
Yu W, Hegarty J, Berg A, Chen X, West G, Kelly A, et al.
PLoS One
. 2011 Jun;
6(5):e20454.
PMID: 21637825
Background: NKX2-3 is associated with inflammatory bowel disease (IBD). NKX2-3 is expressed in microvascular endothelial cells and the muscularis mucosa of the gastrointestinal tract. Human intestinal microvascular endothelial cells (HIMECs)...
8.
Lin Z, Hegarty J, Lin T, Ostrov B, Wang Y, Yu W, et al.
Inflamm Bowel Dis
. 2011 Mar;
17(6):E41-2.
PMID: 21438098
No abstract available.
9.
Yu W, Lin Z, Kelly A, Hegarty J, Poritz L, Wang Y, et al.
J Crohns Colitis
. 2010 Dec;
3(3):189-95.
PMID: 21172269
Aim: To replicate the association of Nkx2-3 rs10883365 SNP with Crohn's disease in patients from a familial IBD registry from the central Pennsylvania area and study mRNA and protein expression...
10.
Sehgal R, Berg A, Hegarty J, Kelly A, Lin Z, Poritz L, et al.
Dis Colon Rectum
. 2010 Oct;
53(11):1487-94.
PMID: 20940596
Purpose: Pouchitis and Crohn's-like complications can plague patients after IPAA. NOD2 is an intracellular sensor for bacterial cell wall peptidoglycan. NOD2 mutations compromise host response to enteric bacteria and are...