Arun P Thottumkara
Overview
Explore the profile of Arun P Thottumkara including associated specialties, affiliations and a list of published articles.
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9
Citations
116
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Recent Articles
1.
Kantarci H, Elvira P, Thottumkara A, OConnell E, Iyer M, Donovan L, et al.
Cell
. 2024 Aug;
187(17):4690-4712.e30.
PMID: 39142281
Electrical excitability-the ability to fire and propagate action potentials-is a signature feature of neurons. How neurons become excitable during development and whether excitability is an intrinsic property of neurons remain...
2.
Miyamoto T, Kim C, Chow J, Dugas J, DeGroot J, Bagdasarian A, et al.
J Biol Chem
. 2024 Jan;
300(2):105630.
PMID: 38199568
Sterile alpha and toll/interleukin receptor motif-containing 1 (SARM1) is a critical regulator of axon degeneration that acts through hydrolysis of NAD following injury. Recent work has defined the mechanisms underlying...
3.
Burnett G, Yang Y, Aggen J, Pitzen J, Gliedt M, Semko C, et al.
J Med Chem
. 2022 Dec;
66(1):149-169.
PMID: 36533617
Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk with other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple allosteric inhibitors...
4.
Craig 2nd R, Fox B, Hu C, Lexa K, Osipov M, Thottumkara A, et al.
J Med Chem
. 2022 Dec;
65(24):16290-16312.
PMID: 36469401
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative...
5.
Lee B, Boyer J, Burnett G, Thottumkara A, Tibrewal N, Wilson S, et al.
Nat Chem Biol
. 2021 Oct;
17(11):1209.
PMID: 34616097
No abstract available.
6.
Lee B, Boyer J, Burnett G, Thottumkara A, Tibrewal N, Wilson S, et al.
Nat Chem Biol
. 2021 Jun;
17(8):925.
PMID: 34188221
No abstract available.
7.
Lee B, Boyer J, Burnett G, Thottumkara A, Tibrewal N, Wilson S, et al.
Nat Chem Biol
. 2021 Jun;
17(10):1065-1074.
PMID: 34168367
The clinical benefits of pan-mTOR active-site inhibitors are limited by toxicity and relief of feedback inhibition of receptor expression. To address these limitations, we designed a series of compounds that...
8.
Thottumkara A, Parsons W, Du Bois J
Angew Chem Int Ed Engl
. 2014 Apr;
53(23):5760-84.
PMID: 24771635
The paralytic agent (+)-saxitoxin (STX), most commonly associated with oceanic red tides and shellfish poisoning, is a potent inhibitor of electrical conduction in cells. Its nefarious effects result from inhibition...
9.
Thottumkara A, Bowsher M, Vinod T
Org Lett
. 2005 Jul;
7(14):2933-6.
PMID: 15987173
[structure: see text] Catalytic use of o-iodoxybenzoic acid (IBX) in the presence of Oxone as a co-oxidant is demonstrated for the oxidation of primary and secondary alcohols in user- and...